Personal profile
Professional Information
Dr. Mumbrekar is an Associate Professor in the Department of Radiation Biology & Toxicology, Manipal School of Life Sciences, Manipal Academy of Higher Education. He has 18 years of research experience, which involve the understanding the biological response to ionizing radiation, with an emphasis on radiosensitivity, neurotoxicology, and the role of mitochondria and gut microbiota in radiation-induced damage. Dr. Mumbrekar’s work integrates multi-omics approaches and animal models to explore how microbial and metabolic factors influence radiation outcomes and therapeutic response. He has contributed to several peer-reviewed publications in Scientific Reports, Life Sciences, and ACS Chemical Neuroscience, and actively collaborates on projects related to space biology, oxidative stress, and radiation mitigation strategies.
Creative Works
Dr. Mumbrekar’s research explores how ionizing radiation impacts cells and tissues — from mitochondrial regulation and oxidative stress to microbiota-driven radioprotection. His interdisciplinary work bridges radiation biology, toxicology, and neurobiology, aiming to develop innovative strategies for improving radiotherapy outcomes and protecting normal tissues.
Research interests
Radiation biology and toxicology, cellular and molecular radiobiology, DNA repair, gut-brain axis in radiation-induced effects, microbiota interactions in radiation contexts, radioprotection, and radioprotective strategies.
Experience
Teaching: 17 years of UG and PG (Biotechnology related subjects, Radiation biology)
Research: 20 years of Radiation biology and Toxicology
Awards and recognition:
ICMR-DHR international fellow (2024)
Mrs & Mr. Raju Award (career-based award) by Indian Society of Radiation Biology, India- 2018
Early Career Research Award by SERB, Govt of India, 2018
Young Scientist Award by Indian Society for Radiation Biology, India- 2016
Young Scientist Award (career-based award) by Society of Radiation Research, India-2016
External positions
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Collaborations and top research areas from the last five years
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Establishing a robust preclinical model to investigate early and late radiation-induced skin reactions
Pai, P. A. N., Mumbrekar, K. D., Mahato, K. K., Prabhu, S. S., Rao, A. C. K. & Prabhu, V., 12-2026, In: Scientific Reports. 16, 1, 9064.Research output: Contribution to journal › Article › peer-review
Open Access -
Multiomics analysis reveals early administration of the Medhya rasayana formulation of Bacopa monnieri (L.) Wettst. and Centella asiatica (L.) Urb. prevents neuroinflammation and cognitive deficits in an AβO-injected AD mouse model
Maruthiyodan, S., Munegowda, G., Thomas, M., Gangadharan, G., Joshi, M. B., Mumbrekar, K. D., Goyal, A., Mahadevan, A., Erayur Mana, A., Thrikovil Sankaran, M., Marthanda Varma Sankaran, V. & Kanive Parashiva, G., 30-01-2026, In: Journal of Ethnopharmacology. 355, 120633.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Citations (Scopus) -
Cancer therapy-induced cardiotoxicity: mechanisms and mitigations
Shil, S., Kumar, P. & Mumbrekar, K. D., 09-2025, In: Heart Failure Reviews. 30, 5, p. 1075-1092 18 p.Research output: Contribution to journal › Review article › peer-review
Open Access12 Link opens in a new tab Citations (Scopus) -
Ferroptosis in space: How microgravity alters iron homeostasis
Sivasubramanian, N., Mumbrekar, K. D. & Prabhu, S., 04-2025, In: Acta Astronautica. 229, p. 512-522 11 p.Research output: Contribution to journal › Review article › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
Inhibition of mitochondrial genome-encoded mitomiR-3 contributes to ZEB1 mediated GPX4 downregulation and pro-ferroptotic lipid metabolism to induce ferroptosis in breast cancer cells
Kandettu, A., Ghosal, J., Tharayil, J. S., Kuthethur, R., Mallya, S., Narasimhamurthy, R. K., Mumbrekar, K. D., Subbannayya, Y., Kumar, N. A., Radhakrishnan, R., Kabekkodu, S. P. & Chakrabarty, S., 07-2025, In: Free Radical Biology and Medicine. 234, p. 151-168 18 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Link opens in a new tab Citations (Scopus)