Немоторные симптомы болезни Паркинсона: обзор

Translated title of the contribution: Spectrum of Non-Motor Symptoms in Parkinson’s Disease — a Review

Syed Zohair Husain Rizvi, Vikram Palimar, Chandni Gupta, Lydia S. Andrade

Research output: Contribution to journalReview articlepeer-review

Abstract

Motor and non-motor symptoms of Parkinson’s disease (PD) and their management have been evaluated in numerous studies. Four classical symptoms, including bradykinesia, tremor, rigidity, and postural abnormalities, are used to establish a clinical diagnosis of PD. However, this research is aimed at exploring the range of non-motor symptoms with an emphasis upon their ability to affect the patients with PD and their quality of life. With a slow onset of the known symptoms like tremor or rhythmic shaking of limbs called “pill-rolling tremor”, slowed movement (bradykinesia), muscle rigidity, stooped and altered posture, loss of the ability to blink or smile, and various speech and writing changes; the disease takes a leap into the non-motor symptoms like dementia, drooling, swallowing issues, difficulty urinating, and constipation. The dopaminergic pathophysiology of PD explains the anxiety, slowness of thought, fatigue, and dysphoria. Knowing the non-motor symptoms is crucial to help the clinician to make early diagnosis and to better understand the prognosis of the spectrum of this disease.

Translated title of the contributionSpectrum of Non-Motor Symptoms in Parkinson’s Disease — a Review
Original languageRussian
Pages (from-to)72-80
Number of pages9
JournalAnnals of Clinical and Experimental Neurology
Volume18
Issue number3
DOIs
Publication statusPublished - 10-2024

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • General Neuroscience
  • General
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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