1-(5'-acetamido-2'-hydroxyphenyl)-3-propan-1-ones: Synthesis, antioxidant and antimicrobial activities

K. L. Shobha; Lalitha Simon; Amita S. Rao; B. C. Ganesh Maiya; K. K. Srinivasan

1-(5'-acetamido-2'-hydroxyphenyl)-3-propan-1-ones: Synthesis, antioxidant and antimicrobial activities

K. L. Shobha, Lalitha Simon^*, Amita S. Rao, B. C. Ganesh Maiya, K. K. Srinivasan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A series of 1-(5'-acetamido-2'-hydroxyphenyl)-3-propan-1-one derivatives were synthesized and evaluated for their antioxidant activity by ABTS radical scavenging assay. Compounds with -OH attached to C-2 of ringB (D6 ) and - OH and -OCH₃ attached to C-4 and C-3 respectively of the ringB(D4 ) were found to be more potent than the standard used. The antibacterial activity of synthesized compounds was investigated against the bacterial strains Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae and antifungal activity against Candida albicans using agar well diffusion method. All the compounds showed good inhibition against Klebsiella pneumoniae at 12.5μg /mL concentration.CompoundsD1 and D10displayed good activity against E.coli as well.

Original language	English
Pages (from-to)	77-82
Number of pages	6
Journal	Der Pharma Chemica
Volume	8
Issue number	14
Publication status	Published - 2016

All Science Journal Classification (ASJC) codes

General Chemistry

Cite this

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abstract = "A series of 1-(5'-acetamido-2'-hydroxyphenyl)-3-propan-1-one derivatives were synthesized and evaluated for their antioxidant activity by ABTS radical scavenging assay. Compounds with -OH attached to C-2 of ringB (D6 ) and - OH and -OCH3 attached to C-4 and C-3 respectively of the ringB(D4 ) were found to be more potent than the standard used. The antibacterial activity of synthesized compounds was investigated against the bacterial strains Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae and antifungal activity against Candida albicans using agar well diffusion method. All the compounds showed good inhibition against Klebsiella pneumoniae at 12.5μg /mL concentration.CompoundsD1 and D10displayed good activity against E.coli as well.",

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T1 - 1-(5'-acetamido-2'-hydroxyphenyl)-3-propan-1-ones

T2 - Synthesis, antioxidant and antimicrobial activities

AU - Shobha, K. L.

AU - Simon, Lalitha

AU - Rao, Amita S.

AU - Ganesh Maiya, B. C.

AU - Srinivasan, K. K.

PY - 2016

Y1 - 2016

N2 - A series of 1-(5'-acetamido-2'-hydroxyphenyl)-3-propan-1-one derivatives were synthesized and evaluated for their antioxidant activity by ABTS radical scavenging assay. Compounds with -OH attached to C-2 of ringB (D6 ) and - OH and -OCH3 attached to C-4 and C-3 respectively of the ringB(D4 ) were found to be more potent than the standard used. The antibacterial activity of synthesized compounds was investigated against the bacterial strains Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae and antifungal activity against Candida albicans using agar well diffusion method. All the compounds showed good inhibition against Klebsiella pneumoniae at 12.5μg /mL concentration.CompoundsD1 and D10displayed good activity against E.coli as well.

AB - A series of 1-(5'-acetamido-2'-hydroxyphenyl)-3-propan-1-one derivatives were synthesized and evaluated for their antioxidant activity by ABTS radical scavenging assay. Compounds with -OH attached to C-2 of ringB (D6 ) and - OH and -OCH3 attached to C-4 and C-3 respectively of the ringB(D4 ) were found to be more potent than the standard used. The antibacterial activity of synthesized compounds was investigated against the bacterial strains Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae and antifungal activity against Candida albicans using agar well diffusion method. All the compounds showed good inhibition against Klebsiella pneumoniae at 12.5μg /mL concentration.CompoundsD1 and D10displayed good activity against E.coli as well.

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ER -

1-(5'-acetamido-2'-hydroxyphenyl)-3-propan-1-ones: Synthesis, antioxidant and antimicrobial activities

Abstract

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