TY - JOUR
T1 - 2-Butyl-5-chloro-3H-imidazole-4-carbaldehyde as a new synthon for the synthesis of fused ring heterocycles via intramolecular 1,3-dipolar cycloaddition reactions
AU - Gaonkar, S. L.
AU - Lokanatha Rai, K. M.
PY - 2010/5
Y1 - 2010/5
N2 - (Chemical Equation Presented) The title compound 2-butyl-5-chloro-3H- imidazole-4-carbaldehyde was transformed into tricyclic heterocycles by substituting the chlorine atom by an unsaturated thiolate or alkoxide and then converting aldehyde function into 1,3-dipole. Chloramine-T was used as an efficient reagent for the generation of 1,3-dipoles, which resulted the formation of fused ring heterocycles via intramolecular 1,3-dipolar cycloaddition reaction. The method is very useful for the construction of many biologically active fused heterocycles.
AB - (Chemical Equation Presented) The title compound 2-butyl-5-chloro-3H- imidazole-4-carbaldehyde was transformed into tricyclic heterocycles by substituting the chlorine atom by an unsaturated thiolate or alkoxide and then converting aldehyde function into 1,3-dipole. Chloramine-T was used as an efficient reagent for the generation of 1,3-dipoles, which resulted the formation of fused ring heterocycles via intramolecular 1,3-dipolar cycloaddition reaction. The method is very useful for the construction of many biologically active fused heterocycles.
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U2 - 10.1002/jhet.250
DO - 10.1002/jhet.250
M3 - Article
AN - SCOPUS:77953010068
SN - 0022-152X
VL - 47
SP - 543
EP - 546
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
IS - 3
ER -