3D Atom based QSAR model of DprE1 inhibitors as Anti-tubercular Agents

K. Poojita, Fajeelath Fathima, Rajdeep Ray, Lalit Kumar, Ruchi Verma

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Tuberculosis disease is world’s biggest threat to health with a high mortality rate. There has been a steady surge in the frequency of MDR-TB and XDR-TB. Hence, it is imperative to encourage the research and development of novel drugs to counteract the infection. Decaprenylphosphoryl-ß-D-ribose-2'α-epimerase 1 (DprE1) is a valuable enzyme which is responsible for the stability and virulence of the infection causing bacteria (Mycobacterium tuberculosis) thereby making it a perfect target for drugs anti TB activity. This study represent atom based 3D QSAR model consisting the derivatives of DprE1 inhibitors and provides guidance and insight to develop and identify new novel molecule which have good therapeutic efficiency as Anti TB drugs.

Original languageEnglish
Pages (from-to)5903-5910
Number of pages8
JournalResearch Journal of Pharmacy and Technology
Issue number11
Publication statusPublished - 11-2021

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Pharmacology (medical)


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