TY - JOUR
T1 - 3D Atom based QSAR model of DprE1 inhibitors as Anti-tubercular Agents
AU - Poojita, K.
AU - Fathima, Fajeelath
AU - Ray, Rajdeep
AU - Kumar, Lalit
AU - Verma, Ruchi
N1 - Publisher Copyright:
© RJPT All right reserved.
PY - 2021/11
Y1 - 2021/11
N2 - Tuberculosis disease is world’s biggest threat to health with a high mortality rate. There has been a steady surge in the frequency of MDR-TB and XDR-TB. Hence, it is imperative to encourage the research and development of novel drugs to counteract the infection. Decaprenylphosphoryl-ß-D-ribose-2'α-epimerase 1 (DprE1) is a valuable enzyme which is responsible for the stability and virulence of the infection causing bacteria (Mycobacterium tuberculosis) thereby making it a perfect target for drugs anti TB activity. This study represent atom based 3D QSAR model consisting the derivatives of DprE1 inhibitors and provides guidance and insight to develop and identify new novel molecule which have good therapeutic efficiency as Anti TB drugs.
AB - Tuberculosis disease is world’s biggest threat to health with a high mortality rate. There has been a steady surge in the frequency of MDR-TB and XDR-TB. Hence, it is imperative to encourage the research and development of novel drugs to counteract the infection. Decaprenylphosphoryl-ß-D-ribose-2'α-epimerase 1 (DprE1) is a valuable enzyme which is responsible for the stability and virulence of the infection causing bacteria (Mycobacterium tuberculosis) thereby making it a perfect target for drugs anti TB activity. This study represent atom based 3D QSAR model consisting the derivatives of DprE1 inhibitors and provides guidance and insight to develop and identify new novel molecule which have good therapeutic efficiency as Anti TB drugs.
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U2 - 10.52711/0974-360X.2021.01026
DO - 10.52711/0974-360X.2021.01026
M3 - Article
AN - SCOPUS:85122163133
SN - 0974-3618
VL - 14
SP - 5903
EP - 5910
JO - Research Journal of Pharmacy and Technology
JF - Research Journal of Pharmacy and Technology
IS - 11
ER -