3D Atom based QSAR model of DprE1 inhibitors as Anti-tubercular Agents

K. Poojita; Fajeelath Fathima; Rajdeep Ray; Lalit Kumar; Ruchi Verma

doi:10.52711/0974-360X.2021.01026

3D Atom based QSAR model of DprE1 inhibitors as Anti-tubercular Agents

K. Poojita, Fajeelath Fathima, Rajdeep Ray, Lalit Kumar, Ruchi Verma

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal
Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Tuberculosis disease is world’s biggest threat to health with a high mortality rate. There has been a steady surge in the frequency of MDR-TB and XDR-TB. Hence, it is imperative to encourage the research and development of novel drugs to counteract the infection. Decaprenylphosphoryl-ß-D-ribose-2'α-epimerase 1 (DprE1) is a valuable enzyme which is responsible for the stability and virulence of the infection causing bacteria (Mycobacterium tuberculosis) thereby making it a perfect target for drugs anti TB activity. This study represent atom based 3D QSAR model consisting the derivatives of DprE1 inhibitors and provides guidance and insight to develop and identify new novel molecule which have good therapeutic efficiency as Anti TB drugs.

Original language	English
Pages (from-to)	5903-5910
Number of pages	8
Journal	Research Journal of Pharmacy and Technology
Volume	14
Issue number	11
DOIs	https://doi.org/10.52711/0974-360X.2021.01026
Publication status	Published - 11-2021

All Science Journal Classification (ASJC) codes

Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.52711/0974-360X.2021.01026

Cite this

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AU - Fathima, Fajeelath

AU - Ray, Rajdeep

AU - Kumar, Lalit

AU - Verma, Ruchi

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3D Atom based QSAR model of DprE1 inhibitors as Anti-tubercular Agents

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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