TY - GEN
T1 - 3D quantitative phase imaging of human red blood cells
AU - Pillai, Anusha
AU - Kamath U, Saritha
AU - Belurkar, Sushma
AU - Asundi, Anand K.
AU - Patil, Ajeetkumar
N1 - Publisher Copyright:
© 2024 SPIE. Downloading of the abstract is permitted for personal use only.
PY - 2024
Y1 - 2024
N2 - RBCs are essential for carrying oxygen throughout the body. Maintaining human health requires an understanding of the various RBC types, their structural defects, and the difficulties in identifying these abnormalities. RBCs are commonly divided into sickle cells, regular disc-shaped erythrocytes, and other physical variations. Hemoglobinopathies including sickle cell disease, thalassemia, and genetic spherocytosis, as well as acquired syndromes like anemia, which can be brought on by dietary shortages or long-term illnesses, are only a few examples of the wide range of RBC abnormalities. Advanced imaging techniques are necessary for identifying and characterizing these anomalies. Label-free, non-invasive, and high-resolution imaging of RBCs is made possible by QPI techniques like the Transport of Intensity Equation (TIE). In our work, with the use of TIE-based 3D QPI, we have extracted quantitative features like cell volume, cell height and cell surface area of human RBCs from the captured images.
AB - RBCs are essential for carrying oxygen throughout the body. Maintaining human health requires an understanding of the various RBC types, their structural defects, and the difficulties in identifying these abnormalities. RBCs are commonly divided into sickle cells, regular disc-shaped erythrocytes, and other physical variations. Hemoglobinopathies including sickle cell disease, thalassemia, and genetic spherocytosis, as well as acquired syndromes like anemia, which can be brought on by dietary shortages or long-term illnesses, are only a few examples of the wide range of RBC abnormalities. Advanced imaging techniques are necessary for identifying and characterizing these anomalies. Label-free, non-invasive, and high-resolution imaging of RBCs is made possible by QPI techniques like the Transport of Intensity Equation (TIE). In our work, with the use of TIE-based 3D QPI, we have extracted quantitative features like cell volume, cell height and cell surface area of human RBCs from the captured images.
UR - https://www.scopus.com/pages/publications/85185562256
UR - https://www.scopus.com/pages/publications/85185562256#tab=citedBy
U2 - 10.1117/12.3023411
DO - 10.1117/12.3023411
M3 - Conference contribution
AN - SCOPUS:85185562256
T3 - Proceedings of SPIE - The International Society for Optical Engineering
BT - International Conference on Optical and Photonic Engineering, icOPEN 2023
A2 - Wang, Haixia
A2 - Cheng, Fang
A2 - Dang, Cuong
A2 - Danner, Aaron
A2 - Kemao, Qian
PB - SPIE
T2 - 2023 International Conference on Optical and Photonic Engineering, icOPEN 2023
Y2 - 27 November 2023 through 1 December 2023
ER -
