@article{629704e189414bb293e2ca8d6d2de023,
title = "5-Aminosalicylic acid reverses endosulfan-induced testicular toxicity in male rats",
abstract = "Pre-treatment with 5-aminosalicylic acid (5-ASA) significantly reduced sperm-shape abnormalities in endosulfan-treated rats. The number of abnormal sperm in the epididymis was markedly increased by endosulfan treatment but pre-treatment with 5-ASA kept these values close to normal. Treatment with 5-ASA at a dose of 25 mg/kg bw was more effective in reducing sperm-shape abnormality and sperm count than at a dose of 50 mg/kg bw. Endosulfan significantly increased the level of lactate dehydrogenase (LDH) in rats but a marked decrease was observed upon pre-treatment with 25 mg/kg bw 5-ASA. Changes in plasma testosterone levels were not significantly correlated with 5-ASA pre-treatment but histopathological analysis of seminiferous tubules and Leydig cells showed significant protection from endosulfan-induced tissue damage such as necrosis. The population of Sertoli cells increased and the lumen of the seminiferous tubules contained a greater number of spermatids. There was a corresponding increase in the number of Leydig cells. A curative study with 5-ASA showed a similar protection from endosulfan-induced toxicity and cellular damage, but the extent of protection was significantly lower. {\textcopyright} 2005 Elsevier B.V. All rights reserved.",
author = "A. Jaiswal and {Kumar Parihar}, V. and {Sudheer Kumar}, M. and S.D. Manjula and B.R. Krishnanand and R. Shanbhag and M.K. Unnikrishnan",
note = "Cited By :18 Export Date: 10 November 2017 CODEN: MRGMF Correspondence Address: Unnikrishnan, M.K.; Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal 576104, India; email: cheruvaloor@yahoo.com Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; endosulfan, 115-29-7; lactate dehydrogenase, 9001-60-9; mesalazine, 89-57-6; testosterone, 58-22-0; Antidotes; Endosulfan, 115-29-7; Insecticides; L-Lactate Dehydrogenase, EC 1.1.1.27; Mesalamine, 89-57-6; Testosterone, 58-22-0 References: (1984) WHO Report International Programme on Chemical Safety, Environmental Health Criteria-40, Endosulfan, p. 28. , WHO, Geneva; Popov, V.B., Protasqvo, G.A., Radilov, A.S., Embryo and genotoxic effects of two endosulfan forms in the culture of rat and mouse pre and pos implantation embryos (1998) Oncogeny, 29, pp. 104-112; Wade, M.G., Desaulniers, D., Leingartner, K., Foster, W.G., Interactions between endosulfan and dieldrin on estrogen-mediated processes in vitro and in vivo (1997) Reprod. 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year = "2005",
doi = "10.1016/j.mrgentox.2005.04.010",
language = "English",
volume = "585",
pages = "50--59",
journal = "Mutation Research - Genetic Toxicology and Environmental Mutagenesis",
issn = "1383-5718",
publisher = "Elsevier",
number = "1-2",
}