5-Aminosalicylic acid reverses endosulfan-induced testicular toxicity in male rats

A. Jaiswal, V. Kumar Parihar, M. Sudheer Kumar, S.D. Manjula, B.R. Krishnanand, R. Shanbhag, M.K. Unnikrishnan

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22 Citations (Scopus)


Pre-treatment with 5-aminosalicylic acid (5-ASA) significantly reduced sperm-shape abnormalities in endosulfan-treated rats. The number of abnormal sperm in the epididymis was markedly increased by endosulfan treatment but pre-treatment with 5-ASA kept these values close to normal. Treatment with 5-ASA at a dose of 25 mg/kg bw was more effective in reducing sperm-shape abnormality and sperm count than at a dose of 50 mg/kg bw. Endosulfan significantly increased the level of lactate dehydrogenase (LDH) in rats but a marked decrease was observed upon pre-treatment with 25 mg/kg bw 5-ASA. Changes in plasma testosterone levels were not significantly correlated with 5-ASA pre-treatment but histopathological analysis of seminiferous tubules and Leydig cells showed significant protection from endosulfan-induced tissue damage such as necrosis. The population of Sertoli cells increased and the lumen of the seminiferous tubules contained a greater number of spermatids. There was a corresponding increase in the number of Leydig cells. A curative study with 5-ASA showed a similar protection from endosulfan-induced toxicity and cellular damage, but the extent of protection was significantly lower. © 2005 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)50-59
Number of pages10
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Issue number1-2
Publication statusPublished - 2005


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