A Case Series of Monoclonal Immunoglobulin-Depositing ProliferatiGlomerulonephritis

Proliferative glomerulonephritis with monoclonal immunoglobulin deposition disease (PGNMIDD) is a rare entity. Wevaluated the clinicopathological features of PGNMIDD and the effectiveness of different treatment regimens in 1cases diagnosed using kidney biopsy. Most had chronic kidney disease followed by acute nephritic syndrome, rapidlprogressive glomerulonephritis, and nephrotic syndrome. Membranoproliferative glomerulonephritis was the moscommon pattern of renal injury. Three patients had abnormal bone marrow studies. Different treatment regimens werdeployed; >60% had partial remission at the end of six months and 30.7% progressed to end stage renal disease.