TY - JOUR
T1 - A combination approach using areca nut and ketoconazole for treating cutaneous candidiasis
AU - Wagle, Manoj M.
AU - Lobo, Kiran Noel
AU - Rajath Kanchan, R.
AU - Chandrashekar, Adithya
AU - Subrahmanyam, V. M.
N1 - Funding Information:
The authors wish to thank authorities of Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India. for providing the facilities needed for the study. The authors wish to acknowledge Dept. of Biotechnology, Govt. of India for sanctioning a project on improving therapeutic efficacy of antifungal drugs I.D. BT/PR10827/AAQ/3/661/2014 which helped the present study.
Publisher Copyright:
© RJPT All right reserved.
PY - 2021/6
Y1 - 2021/6
N2 - Fungal infections caused by Candida are often associated with increasing rates of morbidity and mortality. It is a serious concern for patients with immunocompromised system. The resistance to Ketoconazole, a known antifungal agent is increasing at an alarming rate and a number of such cases have been reported in the recent years. In order to circumvent this problem, a study was carried out using ketoconazole-areca nut (Areca catechu L.) combination. When this combination was tested against Candida albicans, there was an increase in the antifungal activity of ketoconazole. The study can be explored further for the design of suitable topical formulations containing the above combination in the treatment of cutaneous candidiasis.
AB - Fungal infections caused by Candida are often associated with increasing rates of morbidity and mortality. It is a serious concern for patients with immunocompromised system. The resistance to Ketoconazole, a known antifungal agent is increasing at an alarming rate and a number of such cases have been reported in the recent years. In order to circumvent this problem, a study was carried out using ketoconazole-areca nut (Areca catechu L.) combination. When this combination was tested against Candida albicans, there was an increase in the antifungal activity of ketoconazole. The study can be explored further for the design of suitable topical formulations containing the above combination in the treatment of cutaneous candidiasis.
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U2 - 10.52711/0974-360X.2021.00537
DO - 10.52711/0974-360X.2021.00537
M3 - Article
AN - SCOPUS:85112717040
SN - 0974-3618
VL - 14
SP - 3074
EP - 3076
JO - Research Journal of Pharmacy and Technology
JF - Research Journal of Pharmacy and Technology
IS - 6
ER -