A comparative evaluation of the remineralization potential of three commercially available remineralizing agents on white spot lesions in primary teeth: An in vitro study

Background: The focus in caries management has shifted to early detection of caries lesions and targeted noninvasive management of incipient lesions using novel remineralizing agents. Aim: This study aimed to compare and evaluate the remineralization potential of commercially available agents containing nanohydroxyapatite (nanoHA), casein phosphopeptideamorphous calcium phosphate fluoride (CPPACPF), and Tricalcium phosphate (TCP) on artificially induced white spot lesions in primary teeth. Settings and Design: This is an in vitro doubleblind randomized study. Materials and Methods: Forty extracted or exfoliated primary teeth were selected and randomized as follows: Group I: FTCP, Group II: fluoridated dentifrice, Group III: CPPACPF, and Group IV: NanoHA. DIAGNOdent readings and scanning electron microscope (SEM) energy dispersive Xray (EDX) analysis were carried out at baseline. The samples were subjected to the test agents after inducing white spot lesions. The readings were repeated postdemineralization and postremineralization. Statistical Analysis: The data were analyzed using IBM SPSS version 20 software with oneway ANOVA, post hoc Tukey's HSD, and paired ttest. Results: SEM evaluation showed favorable surface changes in all the four study groups after remineralization therapy. Intragroup comparison of DIAGNOdent and EDX readings showed a highly significant difference between baseline, postdemineralization, and postremineralization values. However, the intergroup comparison was statistically nonsignificant. Conclusion: All test agents were comparable in their remineralization potential.