A comprehensive review on the functional role of miRNA clusters in cervical cancer

Srinath Sriharikrishnaa; Femi E. John; Medha Bairy; Sachin Shetty; Padmanaban S. Suresh; Shama P. Kabekkodu

doi:10.2217/epi-2023-0244

A comprehensive review on the functional role of miRNA clusters in cervical cancer

Srinath Sriharikrishnaa
, Femi E. John
, Medha Bairy
, Sachin Shetty
, Padmanaban S. Suresh
, Shama P. Kabekkodu

Research output: Contribution to journal › Review article › peer-review

7 Citations (Scopus)

Abstract

Plain language summary: Cervical cancer is a major global health concern, mostly caused by human papillomavirus infection, resulting in a high number of new cases and fatalities annually. This review examines the role of specific genetic variables known as microRNA clusters (MCs) in the development and progression of cervical cancer. The MCs harbor many microRNAs that control genes related to tumor proliferation, infiltration and dissemination. Understanding the functioning of these MCs can aid in early diagnosis of cervical cancer and predicting its patterns of behavior. We explore the potential benefits of assessing MC expression levels in cancer staging and prognosis, and the development of diagnostic tools and treatments. Targeting these molecular targets could provide interesting opportunities for future cancer treatments.

Original language	English
Pages (from-to)	493-511
Number of pages	19
Journal	Epigenomics
Volume	16
Issue number	7
DOIs	https://doi.org/10.2217/epi-2023-0244
Publication status	Published - 01-04-2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Genetics
Cancer Research

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10.2217/epi-2023-0244

Cite this

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title = "A comprehensive review on the functional role of miRNA clusters in cervical cancer",

abstract = "Plain language summary: Cervical cancer is a major global health concern, mostly caused by human papillomavirus infection, resulting in a high number of new cases and fatalities annually. This review examines the role of specific genetic variables known as microRNA clusters (MCs) in the development and progression of cervical cancer. The MCs harbor many microRNAs that control genes related to tumor proliferation, infiltration and dissemination. Understanding the functioning of these MCs can aid in early diagnosis of cervical cancer and predicting its patterns of behavior. We explore the potential benefits of assessing MC expression levels in cancer staging and prognosis, and the development of diagnostic tools and treatments. Targeting these molecular targets could provide interesting opportunities for future cancer treatments.",

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doi = "10.2217/epi-2023-0244",

language = "English",

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T1 - A comprehensive review on the functional role of miRNA clusters in cervical cancer

AU - Sriharikrishnaa, Srinath

AU - John, Femi E.

AU - Bairy, Medha

AU - Shetty, Sachin

AU - Suresh, Padmanaban S.

AU - Kabekkodu, Shama P.

PY - 2024/4/1

Y1 - 2024/4/1

N2 - Plain language summary: Cervical cancer is a major global health concern, mostly caused by human papillomavirus infection, resulting in a high number of new cases and fatalities annually. This review examines the role of specific genetic variables known as microRNA clusters (MCs) in the development and progression of cervical cancer. The MCs harbor many microRNAs that control genes related to tumor proliferation, infiltration and dissemination. Understanding the functioning of these MCs can aid in early diagnosis of cervical cancer and predicting its patterns of behavior. We explore the potential benefits of assessing MC expression levels in cancer staging and prognosis, and the development of diagnostic tools and treatments. Targeting these molecular targets could provide interesting opportunities for future cancer treatments.

AB - Plain language summary: Cervical cancer is a major global health concern, mostly caused by human papillomavirus infection, resulting in a high number of new cases and fatalities annually. This review examines the role of specific genetic variables known as microRNA clusters (MCs) in the development and progression of cervical cancer. The MCs harbor many microRNAs that control genes related to tumor proliferation, infiltration and dissemination. Understanding the functioning of these MCs can aid in early diagnosis of cervical cancer and predicting its patterns of behavior. We explore the potential benefits of assessing MC expression levels in cancer staging and prognosis, and the development of diagnostic tools and treatments. Targeting these molecular targets could provide interesting opportunities for future cancer treatments.

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U2 - 10.2217/epi-2023-0244

DO - 10.2217/epi-2023-0244

M3 - Review article

C2 - 38511231

AN - SCOPUS:85188760730

SN - 1750-1911

VL - 16

SP - 493

EP - 511

JO - Epigenomics

JF - Epigenomics

IS - 7

ER -

A comprehensive review on the functional role of miRNA clusters in cervical cancer

Abstract

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All Science Journal Classification (ASJC) codes

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