TY - GEN
T1 - A Computational Model of Voltage-Gated Sodium Ion Channel in Human Pulmonary Artery Smooth Muscle Cell
AU - Mahapatra, Chitaranjan
AU - Tripathy, Shuvendra Kumar
AU - Tripathy, Mrunmayee
AU - Gupta, Amritanshu
N1 - Publisher Copyright:
© 2025 IEEE.
PY - 2025
Y1 - 2025
N2 - Pulmonary hypertension (PH) and hypoxic pulmonary vasoconstriction (HPV) are associated with the abnormal contraction of the pulmonary artery smooth muscle cell (PASMC). The cellular electrical activities due to the interaction of various ion channels are the most important determinants of the generation of the vascular tone. We have developed a mathematical model to elucidate the quantitative contribution of the voltage-gated Na+ ion channel to PASMC membrane potential. The voltage-gated Na+ ion channel is built using the classical Hodgkin and Huxley formalism, with the model parameters estimated using experimental data from published literature. The ion channel is then incorporated into a previously published PASMC model to investigate its' modulating effects on the membrane potential. The voltagegated Na+ ion channel conductance alters the resting membrane potential and consequent depolarizations in PASMC. This computational model supports the application of voltage-gated Na+ ion channel inhibitors as new pharmacological targets for PH and HPV.
AB - Pulmonary hypertension (PH) and hypoxic pulmonary vasoconstriction (HPV) are associated with the abnormal contraction of the pulmonary artery smooth muscle cell (PASMC). The cellular electrical activities due to the interaction of various ion channels are the most important determinants of the generation of the vascular tone. We have developed a mathematical model to elucidate the quantitative contribution of the voltage-gated Na+ ion channel to PASMC membrane potential. The voltage-gated Na+ ion channel is built using the classical Hodgkin and Huxley formalism, with the model parameters estimated using experimental data from published literature. The ion channel is then incorporated into a previously published PASMC model to investigate its' modulating effects on the membrane potential. The voltagegated Na+ ion channel conductance alters the resting membrane potential and consequent depolarizations in PASMC. This computational model supports the application of voltage-gated Na+ ion channel inhibitors as new pharmacological targets for PH and HPV.
UR - https://www.scopus.com/pages/publications/105008419330
UR - https://www.scopus.com/pages/publications/105008419330#tab=citedBy
U2 - 10.1109/IC3ECSBHI63591.2025.10991320
DO - 10.1109/IC3ECSBHI63591.2025.10991320
M3 - Conference contribution
AN - SCOPUS:105008419330
T3 - 2025 International Conference on Cognitive Computing in Engineering, Communications, Sciences and Biomedical Health Informatics, IC3ECSBHI 2025
SP - 1099
EP - 1103
BT - 2025 International Conference on Cognitive Computing in Engineering, Communications, Sciences and Biomedical Health Informatics, IC3ECSBHI 2025
A2 - Ansari, M. A.
A2 - Pal, Kirti
A2 - Kumar, Sushil
A2 - Baghel, Anurag Singh
A2 - Ashraf, Moh'd Tashfeen
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2025 International Conference on Cognitive Computing in Engineering, Communications, Sciences and Biomedical Health Informatics, IC3ECSBHI 2025
Y2 - 16 January 2025 through 18 January 2025
ER -