TY - JOUR
T1 - A critical analysis of the concept of secondary oral hypoglycemic agent (OHA) failure in type 2 diabetes at a tertiary care hospital
AU - Vidyasagar, Sudha
AU - Nataraj,
AU - Varma, Muralidhar
AU - Prashanth, C. K.
AU - Rao, Yeshwanth Karkal
AU - Kavitha, B.
PY - 2011/9/1
Y1 - 2011/9/1
N2 - Data from UKPDS study suggests that the onset of β cell dysfunction in diabetes occurs well before the development of hyperglycemia. To study the concept of secondary OHA failure in type 2 diabetes patients of more than 10 years duration in a tertiary care hospital. A retrospective analysis of all the cases of type 2 diabetes mellitus of more than 10 years duration from 2002 to 2003 was done and the data was divided into three groups: oral hypoglycemic agents (OHA) only, Insulin only, OHA + insulin. ANOVA/Students t test was the primary statistical test used. Odds ratio and 95% CI were calculated to compare risks of other diseases and drug use. 62.35% were on only OHAs, 8.82% on only insulin and 28.82% on both insulin and OHAs. This confirms good efficacy of OHAs. Diabetic population in our study tends to have a preserved beta cell function and secondary OHA failure is a late feature.
AB - Data from UKPDS study suggests that the onset of β cell dysfunction in diabetes occurs well before the development of hyperglycemia. To study the concept of secondary OHA failure in type 2 diabetes patients of more than 10 years duration in a tertiary care hospital. A retrospective analysis of all the cases of type 2 diabetes mellitus of more than 10 years duration from 2002 to 2003 was done and the data was divided into three groups: oral hypoglycemic agents (OHA) only, Insulin only, OHA + insulin. ANOVA/Students t test was the primary statistical test used. Odds ratio and 95% CI were calculated to compare risks of other diseases and drug use. 62.35% were on only OHAs, 8.82% on only insulin and 28.82% on both insulin and OHAs. This confirms good efficacy of OHAs. Diabetic population in our study tends to have a preserved beta cell function and secondary OHA failure is a late feature.
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U2 - 10.1007/s13410-011-0037-z
DO - 10.1007/s13410-011-0037-z
M3 - Article
AN - SCOPUS:84856273839
SN - 0973-3930
VL - 31
SP - 161
EP - 165
JO - International Journal of Diabetes in Developing Countries
JF - International Journal of Diabetes in Developing Countries
IS - 3
ER -
