TY - JOUR
T1 - A critical analysis of the recent developments in multi-stimuli responsive smart hydrogels for cancer treatment
AU - Mateti, Tarun
AU - K, Likhith
AU - Laha, Anindita
AU - Thakur, Goutam
N1 - Funding Information:
Likhith K and Goutam Thakur gratefully acknowledge the Intramural funding support from Manipal Academy of Higher Education (MAHE/DREG/PhD/IMF2019).
Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2023/3
Y1 - 2023/3
N2 - Hydrogels are emerging drug delivery vehicles as they provide better biocompatibility, less toxicity, and biodegradability than other systems. Smart hydrogels interact with external stimuli and release their constituents according to their logic gate algorithm. Multi-stimuli drug-loaded hydrogels respond to the tumor microenvironment's features and permit controlled in situ release and efficient drug delivery. Thermo–pH-sensitive hydrogels react to the temperature and the acidic microenvironment of tumor cells, whereas redox–pH hydrogels react with glutathione in the tumor cell cytoplasm. Here, we comprehensively classify and analyze the recent developments in multi-stimuli responsive hydrogels used against cancer cell lines for their cytotoxicity.
AB - Hydrogels are emerging drug delivery vehicles as they provide better biocompatibility, less toxicity, and biodegradability than other systems. Smart hydrogels interact with external stimuli and release their constituents according to their logic gate algorithm. Multi-stimuli drug-loaded hydrogels respond to the tumor microenvironment's features and permit controlled in situ release and efficient drug delivery. Thermo–pH-sensitive hydrogels react to the temperature and the acidic microenvironment of tumor cells, whereas redox–pH hydrogels react with glutathione in the tumor cell cytoplasm. Here, we comprehensively classify and analyze the recent developments in multi-stimuli responsive hydrogels used against cancer cell lines for their cytotoxicity.
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U2 - 10.1016/j.cobme.2022.100424
DO - 10.1016/j.cobme.2022.100424
M3 - Review article
AN - SCOPUS:85141987701
SN - 2468-4511
VL - 25
JO - Current Opinion in Biomedical Engineering
JF - Current Opinion in Biomedical Engineering
M1 - 100424
ER -
