A critical analysis of the recent developments in multi-stimuli responsive smart hydrogels for cancer treatment

Tarun Mateti; Likhith K; Anindita Laha; Goutam Thakur

doi:10.1016/j.cobme.2022.100424

A critical analysis of the recent developments in multi-stimuli responsive smart hydrogels for cancer treatment

Tarun Mateti
, Likhith K
, Anindita Laha
, Goutam Thakur^*

^*Corresponding author for this work

Manipal Institute of Technology, Manipal

Research output: Contribution to journal › Review article › peer-review

24 Citations (Scopus)

Abstract

Hydrogels are emerging drug delivery vehicles as they provide better biocompatibility, less toxicity, and biodegradability than other systems. Smart hydrogels interact with external stimuli and release their constituents according to their logic gate algorithm. Multi-stimuli drug-loaded hydrogels respond to the tumor microenvironment's features and permit controlled in situ release and efficient drug delivery. Thermo–pH-sensitive hydrogels react to the temperature and the acidic microenvironment of tumor cells, whereas redox–pH hydrogels react with glutathione in the tumor cell cytoplasm. Here, we comprehensively classify and analyze the recent developments in multi-stimuli responsive hydrogels used against cancer cell lines for their cytotoxicity.

Original language	English
Article number	100424
Journal	Current Opinion in Biomedical Engineering
Volume	25
DOIs	https://doi.org/10.1016/j.cobme.2022.100424
Publication status	Published - 03-2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Bioengineering
Medicine (miscellaneous)
Biomaterials
Biomedical Engineering

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10.1016/j.cobme.2022.100424

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title = "A critical analysis of the recent developments in multi-stimuli responsive smart hydrogels for cancer treatment",

abstract = "Hydrogels are emerging drug delivery vehicles as they provide better biocompatibility, less toxicity, and biodegradability than other systems. Smart hydrogels interact with external stimuli and release their constituents according to their logic gate algorithm. Multi-stimuli drug-loaded hydrogels respond to the tumor microenvironment's features and permit controlled in situ release and efficient drug delivery. Thermo–pH-sensitive hydrogels react to the temperature and the acidic microenvironment of tumor cells, whereas redox–pH hydrogels react with glutathione in the tumor cell cytoplasm. Here, we comprehensively classify and analyze the recent developments in multi-stimuli responsive hydrogels used against cancer cell lines for their cytotoxicity.",

author = "Tarun Mateti and Likhith K and Anindita Laha and Goutam Thakur",

note = "Funding Information: Likhith K and Goutam Thakur gratefully acknowledge the Intramural funding support from Manipal Academy of Higher Education (MAHE/DREG/PhD/IMF2019). Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

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AU - Mateti, Tarun

AU - K, Likhith

AU - Laha, Anindita

AU - Thakur, Goutam

N1 - Funding Information: Likhith K and Goutam Thakur gratefully acknowledge the Intramural funding support from Manipal Academy of Higher Education (MAHE/DREG/PhD/IMF2019). Publisher Copyright: © 2022 Elsevier Inc.

PY - 2023/3

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N2 - Hydrogels are emerging drug delivery vehicles as they provide better biocompatibility, less toxicity, and biodegradability than other systems. Smart hydrogels interact with external stimuli and release their constituents according to their logic gate algorithm. Multi-stimuli drug-loaded hydrogels respond to the tumor microenvironment's features and permit controlled in situ release and efficient drug delivery. Thermo–pH-sensitive hydrogels react to the temperature and the acidic microenvironment of tumor cells, whereas redox–pH hydrogels react with glutathione in the tumor cell cytoplasm. Here, we comprehensively classify and analyze the recent developments in multi-stimuli responsive hydrogels used against cancer cell lines for their cytotoxicity.

AB - Hydrogels are emerging drug delivery vehicles as they provide better biocompatibility, less toxicity, and biodegradability than other systems. Smart hydrogels interact with external stimuli and release their constituents according to their logic gate algorithm. Multi-stimuli drug-loaded hydrogels respond to the tumor microenvironment's features and permit controlled in situ release and efficient drug delivery. Thermo–pH-sensitive hydrogels react to the temperature and the acidic microenvironment of tumor cells, whereas redox–pH hydrogels react with glutathione in the tumor cell cytoplasm. Here, we comprehensively classify and analyze the recent developments in multi-stimuli responsive hydrogels used against cancer cell lines for their cytotoxicity.

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DO - 10.1016/j.cobme.2022.100424

M3 - Review article

AN - SCOPUS:85141987701

SN - 2468-4511

VL - 25

JO - Current Opinion in Biomedical Engineering

JF - Current Opinion in Biomedical Engineering

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ER -

A critical analysis of the recent developments in multi-stimuli responsive smart hydrogels for cancer treatment

Abstract

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All Science Journal Classification (ASJC) codes

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