A critical review on antiviral peptides derived from viral glycoproteins and host receptors to decoy herpes simplex virus

Rakesh Rahangdale, Tenzin Tender, Sridevi Balireddy, Kamini Goswami, Mukesh Pasupuleti, Raghu Chandrashekar Hariharapura

Research output: Contribution to journalReview articlepeer-review

Abstract

The health of the human population has been continuously challenged by viral infections. Herpes simplex virus (HSV) is one of the common causes of illness and can lead to death in immunocompromised patients. Existing anti-HSV therapies are not completely successful in eliminating the infection due to anti-viral drug resistance, ineffectiveness against the latent virus and high toxicity over prolonged use. There is a need to update our knowledge of the current challenges faced in anti-HSV therapeutics and realize the necessity of developing alternative treatment approaches. Protein therapeutics are now being explored as a novel approach due to their high specificity and low toxicity. This review highlights the significance of HSV viral glycoproteins and host receptors in the pathogenesis of HSV infection. Proteins or peptides derived from HSV glycoproteins gC, gB, gD, gH and host cell receptors (HSPG, nectin and HVEM) that act as decoys to inhibit HSV attachment, entry, or fusion have been discussed. Few researchers have tried to improve the efficacy and stability of the identified peptides by modifying them using a peptidomimetic approach. With these efforts, we think developing an alternative treatment option for immunocompromised patients and drug-resistant organisms is not far off.

Original languageEnglish
Pages (from-to)2036-2052
Number of pages17
JournalMicrobial Biotechnology
Volume16
Issue number11
DOIs
Publication statusAccepted/In press - 2023

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Applied Microbiology and Biotechnology

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