TY - JOUR
T1 - A facile synthesis of N-substituted 2,5-dimethylpyrroles with saccharin as a green catalyst
AU - Bhandari, Namratha
AU - Gaonkar, Santosh L.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - [MediaObject not available: see fulltext.]The paper describes a convenient method for the preparation of N-substituted 2,5-dimethylpyrroles using edible sweetener saccharin. Various heterocyclic and aromatic hydrazides have been converted to their corresponding Paal-Knorr pyrroles at room temperature in methanol with saccharin as a green catalyst. Saccharin can be recycled for the next two runs without apparent loss in its activity. Here we propose a method which is speedy, proficient, and ecologically safe.
AB - [MediaObject not available: see fulltext.]The paper describes a convenient method for the preparation of N-substituted 2,5-dimethylpyrroles using edible sweetener saccharin. Various heterocyclic and aromatic hydrazides have been converted to their corresponding Paal-Knorr pyrroles at room temperature in methanol with saccharin as a green catalyst. Saccharin can be recycled for the next two runs without apparent loss in its activity. Here we propose a method which is speedy, proficient, and ecologically safe.
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U2 - 10.1007/s10593-015-1701-x
DO - 10.1007/s10593-015-1701-x
M3 - Article
AN - SCOPUS:84953357977
SN - 0009-3122
VL - 51
SP - 320
EP - 323
JO - Chemistry of Heterocyclic Compounds
JF - Chemistry of Heterocyclic Compounds
IS - 4
ER -