TY - JOUR
T1 - A NEW MICROWAVE-ASSISTED METHOD FOR THE SYNTHESIS OF 2-SUBSTITUTED-THIAZOL-4(5H)-ONE VIA HANTZSCH CONDENSATION
AU - Nayak, Swarnagowri
AU - Gaonkar, Santosh L.
N1 - Funding Information:
Sincere gratitude from Ms. Swarnagowri Nayak to DST, Government of India [DST-Inspire Fellowship 2018 \ IF180662 dated 25.09.2019] and MAHE, Manipal for funding the research work.
Publisher Copyright:
© 2022, Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma. All rights reserved.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - A new microwave-assisted method is developed for the synthesis of 2-substituted-thiazol-4(5H)-ones via Hantzsch condensation by a simple experimental protocol without using any catalyst. The products were isolated in excellent yield without any purification. Synthesized compounds were characterized by applying FTIR,1 H NMR,13 C NMR, and mass spectral studies and a plausible mechanism is proposed for the formation of the product. The method is versatile for the preparation of a new class of 2-substituted-thiazol-4(5H)-ones.
AB - A new microwave-assisted method is developed for the synthesis of 2-substituted-thiazol-4(5H)-ones via Hantzsch condensation by a simple experimental protocol without using any catalyst. The products were isolated in excellent yield without any purification. Synthesized compounds were characterized by applying FTIR,1 H NMR,13 C NMR, and mass spectral studies and a plausible mechanism is proposed for the formation of the product. The method is versatile for the preparation of a new class of 2-substituted-thiazol-4(5H)-ones.
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U2 - 10.31788/RJC.2022.1516578
DO - 10.31788/RJC.2022.1516578
M3 - Article
AN - SCOPUS:85126917096
SN - 0974-1496
VL - 15
SP - 310
EP - 315
JO - Rasayan Journal of Chemistry
JF - Rasayan Journal of Chemistry
IS - 1
ER -