A NEW MICROWAVE-ASSISTED METHOD FOR THE SYNTHESIS OF 2-SUBSTITUTED-THIAZOL-4(5H)-ONE VIA HANTZSCH CONDENSATION

Swarnagowri Nayak; Santosh L. Gaonkar

doi:10.31788/RJC.2022.1516578

A NEW MICROWAVE-ASSISTED METHOD FOR THE SYNTHESIS OF 2-SUBSTITUTED-THIAZOL-4(5H)-ONE VIA HANTZSCH CONDENSATION

Swarnagowri Nayak
, Santosh L. Gaonkar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A new microwave-assisted method is developed for the synthesis of 2-substituted-thiazol-4(5H)-ones via Hantzsch condensation by a simple experimental protocol without using any catalyst. The products were isolated in excellent yield without any purification. Synthesized compounds were characterized by applying FTIR,¹ H NMR,¹³ C NMR, and mass spectral studies and a plausible mechanism is proposed for the formation of the product. The method is versatile for the preparation of a new class of 2-substituted-thiazol-4(5H)-ones.

Original language	English
Pages (from-to)	310-315
Number of pages	6
Journal	Rasayan Journal of Chemistry
Volume	15
Issue number	1
DOIs	https://doi.org/10.31788/RJC.2022.1516578
Publication status	Published - 01-01-2022

All Science Journal Classification (ASJC) codes

General Chemistry
Biochemistry
General Chemical Engineering
General Energy
Pharmacology, Toxicology and Pharmaceutics(all)

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10.31788/RJC.2022.1516578

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title = "A NEW MICROWAVE-ASSISTED METHOD FOR THE SYNTHESIS OF 2-SUBSTITUTED-THIAZOL-4(5H)-ONE VIA HANTZSCH CONDENSATION",

abstract = "A new microwave-assisted method is developed for the synthesis of 2-substituted-thiazol-4(5H)-ones via Hantzsch condensation by a simple experimental protocol without using any catalyst. The products were isolated in excellent yield without any purification. Synthesized compounds were characterized by applying FTIR,1 H NMR,13 C NMR, and mass spectral studies and a plausible mechanism is proposed for the formation of the product. The method is versatile for the preparation of a new class of 2-substituted-thiazol-4(5H)-ones.",

author = "Swarnagowri Nayak and Gaonkar, \{Santosh L.\}",

note = "Funding Information: Sincere gratitude from Ms. Swarnagowri Nayak to DST, Government of India [DST-Inspire Fellowship 2018 \textbackslash{} IF180662 dated 25.09.2019] and MAHE, Manipal for funding the research work. Publisher Copyright: {\textcopyright} 2022, Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma. All rights reserved.",

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doi = "10.31788/RJC.2022.1516578",

language = "English",

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AU - Gaonkar, Santosh L.

N1 - Funding Information: Sincere gratitude from Ms. Swarnagowri Nayak to DST, Government of India [DST-Inspire Fellowship 2018 \ IF180662 dated 25.09.2019] and MAHE, Manipal for funding the research work. Publisher Copyright: © 2022, Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma. All rights reserved.

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N2 - A new microwave-assisted method is developed for the synthesis of 2-substituted-thiazol-4(5H)-ones via Hantzsch condensation by a simple experimental protocol without using any catalyst. The products were isolated in excellent yield without any purification. Synthesized compounds were characterized by applying FTIR,1 H NMR,13 C NMR, and mass spectral studies and a plausible mechanism is proposed for the formation of the product. The method is versatile for the preparation of a new class of 2-substituted-thiazol-4(5H)-ones.

AB - A new microwave-assisted method is developed for the synthesis of 2-substituted-thiazol-4(5H)-ones via Hantzsch condensation by a simple experimental protocol without using any catalyst. The products were isolated in excellent yield without any purification. Synthesized compounds were characterized by applying FTIR,1 H NMR,13 C NMR, and mass spectral studies and a plausible mechanism is proposed for the formation of the product. The method is versatile for the preparation of a new class of 2-substituted-thiazol-4(5H)-ones.

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A NEW MICROWAVE-ASSISTED METHOD FOR THE SYNTHESIS OF 2-SUBSTITUTED-THIAZOL-4(5H)-ONE VIA HANTZSCH CONDENSATION

Abstract

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