A novel and convenient approach toward the synthesis of Rizatriptan

Pankaj R. Chaudhari, Nandu B. Bhise, Girij P. Singh, Varadaraj Bhat, Gautham G. Shenoy, Rohidas Sulake

Research output: Contribution to journalArticlepeer-review


Given article describes the synthesis of 5-HT1 agonist rizatriptan via the construction of an indole ring on 3-Methyl-4-nitrobenzoic acid methyl ester by Leimgruber-Batcho reaction. The indole intermediate obtained is then further converted to rizatriptan, a triptan-class compound. Using simple, facile and an efficient methodology, rizatriptan was prepared. Graphical abstract: The construction of the indole ring was carried out on 3-methyl-4-nitrobenzoic acid methyl ester. The indole intermediate obtained was then treated with Oxalyl chloride to get an oxoacetyl indole carboxylate intermediate. The Intermediate obtained was then further converted to rizatriptan.[Figure not available: see fulltext.].

Original languageEnglish
Article number67
JournalJournal of Chemical Sciences
Issue number3
Publication statusPublished - 09-2023

All Science Journal Classification (ASJC) codes

  • Chemistry(all)


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