TY - JOUR
T1 - A novel gene THSD7A is associated with obesity
AU - Nizamuddin, S.
AU - Govindaraj, P.
AU - Saxena, S.
AU - Kashyap, M.
AU - Mishra, A.
AU - Singh, S.
AU - Rotti, H.
AU - Raval, R.
AU - Nayak, J.
AU - Bhat, B. K.
AU - Prasanna, B. V.
AU - Dhumal, V. R.
AU - Bhale, S.
AU - Joshi, K. S.
AU - Dedge, A. P.
AU - Bharadwaj, R.
AU - Gangadharan, G. G.
AU - Nair, S.
AU - Gopinath, P. M.
AU - Patwardhan, B.
AU - Kondaiah, P.
AU - Satyamoorthy, K.
AU - Valiathan, M. S.
AU - Thangaraj, K.
PY - 2015/11/1
Y1 - 2015/11/1
N2 - Body mass index (BMI) is a non-invasive measurement of obesity. It is commonly used for assessing adiposity and obesity-related risk prediction. Genetic differences between ethnic groups are important factors, which contribute to the variation in phenotypic effects. India inhabited by the first out-of-Africa human population and the contemporary Indian populations are admixture of two ancestral populations; ancestral north Indians (ANI) and ancestral south Indians (ASI). Although ANI are related to Europeans, ASI are not related to any group outside Indian-subcontinent. Hence, we expect novel genetic loci associated with BMI. In association analysis, we found eight genic SNPs in extreme of distribution (P≤3.75 × 10 -5), of which WWOX has already been reported to be associated with obesity-related traits hence excluded from further study. Interestingly, we observed rs1526538, an intronic SNP of THSD7A; a novel gene significantly associated with obesity (P=2.88 × 10 -5, 8.922 × 10 -6 and 2.504 × 10 -9 in discovery, replication and combined stages, respectively). THSD7A is neural N-glycoprotein, which promotes angiogenesis and it is well known that angiogenesis modulates obesity, adipose metabolism and insulin sensitivity, hence our result find a correlation. This information can be used for drug target, early diagnosis of obesity and treatment.
AB - Body mass index (BMI) is a non-invasive measurement of obesity. It is commonly used for assessing adiposity and obesity-related risk prediction. Genetic differences between ethnic groups are important factors, which contribute to the variation in phenotypic effects. India inhabited by the first out-of-Africa human population and the contemporary Indian populations are admixture of two ancestral populations; ancestral north Indians (ANI) and ancestral south Indians (ASI). Although ANI are related to Europeans, ASI are not related to any group outside Indian-subcontinent. Hence, we expect novel genetic loci associated with BMI. In association analysis, we found eight genic SNPs in extreme of distribution (P≤3.75 × 10 -5), of which WWOX has already been reported to be associated with obesity-related traits hence excluded from further study. Interestingly, we observed rs1526538, an intronic SNP of THSD7A; a novel gene significantly associated with obesity (P=2.88 × 10 -5, 8.922 × 10 -6 and 2.504 × 10 -9 in discovery, replication and combined stages, respectively). THSD7A is neural N-glycoprotein, which promotes angiogenesis and it is well known that angiogenesis modulates obesity, adipose metabolism and insulin sensitivity, hence our result find a correlation. This information can be used for drug target, early diagnosis of obesity and treatment.
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U2 - 10.1038/ijo.2015.144
DO - 10.1038/ijo.2015.144
M3 - Article
C2 - 26238973
AN - SCOPUS:84947025780
SN - 0307-0565
VL - 39
SP - 1662
EP - 1665
JO - International Journal of Obesity
JF - International Journal of Obesity
IS - 11
ER -