A novel series of homoallylic amines as potential antimicrobials

U. Sankappa Rai; Arun M. Isloor; Prakash Shetty; Nishitha Isloor; Mahesh Padaki; Hoong Kun Fun

doi:10.1007/s00044-011-9607-3

A novel series of homoallylic amines as potential antimicrobials

U. Sankappa Rai, Arun M. Isloor, Prakash Shetty, Nishitha Isloor, Mahesh Padaki, Hoong Kun Fun

Department of Chemistry, Manipal Institute of Technology, Manipal

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

An efficient catalytic three-component reaction of aldehydes, amines, and allyltributylstannate has been successfully developed to produce homoallylic amines at 25°C, in excellent yields, in the presence of 1 mol% of trifluoroacetic acid an inexpensive and environmentally friendly catalyst. Newly synthesized compounds were confirmed by spectral studies. Compound 3o was characterized by single crystal X-ray analysis. All the compounds were also screened for their antimicrobial activity. Halogen-substituted compounds namely 3d, 3g, 3n, and 3o have showed excellent antibacterial activity.

Original language	English
Pages (from-to)	1090-1097
Number of pages	8
Journal	Medicinal Chemistry Research
Volume	21
Issue number	7
DOIs	https://doi.org/10.1007/s00044-011-9607-3
Publication status	Published - 01-07-2012

All Science Journal Classification (ASJC) codes

Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

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10.1007/s00044-011-9607-3

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abstract = "An efficient catalytic three-component reaction of aldehydes, amines, and allyltributylstannate has been successfully developed to produce homoallylic amines at 25°C, in excellent yields, in the presence of 1 mol% of trifluoroacetic acid an inexpensive and environmentally friendly catalyst. Newly synthesized compounds were confirmed by spectral studies. Compound 3o was characterized by single crystal X-ray analysis. All the compounds were also screened for their antimicrobial activity. Halogen-substituted compounds namely 3d, 3g, 3n, and 3o have showed excellent antibacterial activity.",

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AU - Rai, U. Sankappa

AU - Isloor, Arun M.

AU - Shetty, Prakash

AU - Isloor, Nishitha

AU - Padaki, Mahesh

AU - Fun, Hoong Kun

PY - 2012/7/1

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N2 - An efficient catalytic three-component reaction of aldehydes, amines, and allyltributylstannate has been successfully developed to produce homoallylic amines at 25°C, in excellent yields, in the presence of 1 mol% of trifluoroacetic acid an inexpensive and environmentally friendly catalyst. Newly synthesized compounds were confirmed by spectral studies. Compound 3o was characterized by single crystal X-ray analysis. All the compounds were also screened for their antimicrobial activity. Halogen-substituted compounds namely 3d, 3g, 3n, and 3o have showed excellent antibacterial activity.

AB - An efficient catalytic three-component reaction of aldehydes, amines, and allyltributylstannate has been successfully developed to produce homoallylic amines at 25°C, in excellent yields, in the presence of 1 mol% of trifluoroacetic acid an inexpensive and environmentally friendly catalyst. Newly synthesized compounds were confirmed by spectral studies. Compound 3o was characterized by single crystal X-ray analysis. All the compounds were also screened for their antimicrobial activity. Halogen-substituted compounds namely 3d, 3g, 3n, and 3o have showed excellent antibacterial activity.

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A novel series of homoallylic amines as potential antimicrobials

Abstract

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