A novel series of homoallylic amines as potential antimicrobials

U. Sankappa Rai; Arun M. Isloor; Prakash Shetty; Nishitha Isloor; Mahesh Padaki; Hoong Kun Fun

doi:10.1007/s00044-011-9607-3

A novel series of homoallylic amines as potential antimicrobials

U. Sankappa Rai
, Arun M. Isloor^*
, Prakash Shetty
, Nishitha Isloor
, Mahesh Padaki
, Hoong Kun Fun

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

An efficient catalytic three-component reaction of aldehydes, amines, and allyltributylstannate has been successfully developed to produce homoallylic amines at 25°C, in excellent yields, in the presence of 1 mol% of trifluoroacetic acid an inexpensive and environmentally friendly catalyst. Newly synthesized compounds were confirmed by spectral studies. Compound 3o was characterized by single crystal X-ray analysis. All the compounds were also screened for their antimicrobial activity. Halogen-substituted compounds namely 3d, 3g, 3n, and 3o have showed excellent antibacterial activity.

Original language	English
Pages (from-to)	1090-1097
Number of pages	8
Journal	Medicinal Chemistry Research
Volume	21
Issue number	7
DOIs	https://doi.org/10.1007/s00044-011-9607-3
Publication status	Published - 01-07-2012

All Science Journal Classification (ASJC) codes

Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

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10.1007/s00044-011-9607-3

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abstract = "An efficient catalytic three-component reaction of aldehydes, amines, and allyltributylstannate has been successfully developed to produce homoallylic amines at 25°C, in excellent yields, in the presence of 1 mol\% of trifluoroacetic acid an inexpensive and environmentally friendly catalyst. Newly synthesized compounds were confirmed by spectral studies. Compound 3o was characterized by single crystal X-ray analysis. All the compounds were also screened for their antimicrobial activity. Halogen-substituted compounds namely 3d, 3g, 3n, and 3o have showed excellent antibacterial activity.",

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AU - Rai, U. Sankappa

AU - Isloor, Arun M.

AU - Shetty, Prakash

AU - Isloor, Nishitha

AU - Padaki, Mahesh

AU - Fun, Hoong Kun

PY - 2012/7/1

Y1 - 2012/7/1

N2 - An efficient catalytic three-component reaction of aldehydes, amines, and allyltributylstannate has been successfully developed to produce homoallylic amines at 25°C, in excellent yields, in the presence of 1 mol% of trifluoroacetic acid an inexpensive and environmentally friendly catalyst. Newly synthesized compounds were confirmed by spectral studies. Compound 3o was characterized by single crystal X-ray analysis. All the compounds were also screened for their antimicrobial activity. Halogen-substituted compounds namely 3d, 3g, 3n, and 3o have showed excellent antibacterial activity.

AB - An efficient catalytic three-component reaction of aldehydes, amines, and allyltributylstannate has been successfully developed to produce homoallylic amines at 25°C, in excellent yields, in the presence of 1 mol% of trifluoroacetic acid an inexpensive and environmentally friendly catalyst. Newly synthesized compounds were confirmed by spectral studies. Compound 3o was characterized by single crystal X-ray analysis. All the compounds were also screened for their antimicrobial activity. Halogen-substituted compounds namely 3d, 3g, 3n, and 3o have showed excellent antibacterial activity.

UR - https://www.scopus.com/pages/publications/84861874719

UR - https://www.scopus.com/pages/publications/84861874719#tab=citedBy

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SP - 1090

EP - 1097

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

IS - 7

ER -

A novel series of homoallylic amines as potential antimicrobials

Abstract

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