A Numerical Approach to Hemodialyzer Design Optimization: Comparison with the Existing Transport Models

– An optimal dialyzer design that provides maximum solute clearance is not available in literature as no analytical theories proposed could include all the factors that are involved in hemodialyzer. All the current dialyzer membranes fail to meet the tradeoff of selectivity and permeability as these hollow fiber membranes still fail in effective toxin clearance and retention of needed solutes. Literatures proposing transport models and optimization factors gain explicit interest now. This paper numerically derives the factors and parameters responsible for effective toxin removal. Thus, the parameters derived will be used in modeling dialyzer membranes by using finite element analysis software and thus the membrane performance will be evaluated. Literatures from standard journals, highlighting experimental data results are then used to benchmark the mathematical model thus proposed. The simulation models in this work putforward optimal designs that can be considered for future works.