A randomized trial of once daily versus twice daily dosing of oral iron in CKD

Vivek Sood, Kajal Kamboj, Prateek Bhatia, Vishal Sharma, Monica Kundu, Arpita Ghosh, Sanjay Kumar Singh, Thakur Sen, Prabhjot Kaur, Raja Ramachandran, Manish Rathi, Harbir Singh Kohli, Krishan Lal Gupta, Samir Malhotra, Ashok Kumar Yadav, Vivek Kumar, Vivekanand Jha

Research output: Contribution to journalArticlepeer-review


We investigated the effect of two dosing regimens of oral iron on iron status and hematological parameters in patients with CKD. In this single center, open label, randomized, active controlled clinical trial, stable adult patients with CKD stage G3–4 with percentage transferrin saturation (%TSAT) ≤ 30% and serum ferritin ≤ 500 ng/ml were eligible. Participants were randomized to receive either 100 mg of ferrous ascorbate once daily (OD group) or 100 mg of ferrous ascorbate twice daily (BD group, total daily dose 200 mg). The primary outcome was change in %TSAT between groups over 12 weeks. The secondary outcomes were changes in other iron status and hematological parameters, serum interleukin-6 (IL-6) and hepcidin. 80 participants were enrolled out of which 76 completed the study. Change in %TSAT was not significantly different between groups (β = − 1.43, 95% CI − 3.99 to 1.12, BD group as reference). The rise in serum ferritin was less in the OD group as compared to BD group (β = − 0.36, 95% CI − 0.61 to − 0.10) whereas MCHC increased in the OD group as compared to decrease in the BD group (β = 0.37, 95% CI 0.067–0.67). These observations need exploration to ascertain the impact of different oral iron dosing strategies in CKD.

Original languageEnglish
Article number141
JournalScientific Reports
Issue number1
Publication statusPublished - 12-2023

All Science Journal Classification (ASJC) codes

  • General


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