A rare case of ALK negative CD30+ primary cutaneous anaplastic large cell lymphoma in a young adult

H. B. Sridevi; P. R. Shanthala; C. V. Raghuveer; Ananth K. Prabhu; Jallaluddin K.C. Akbar; G. S. Shivaprasad; Pooja K. Suresh; Sanjay Navani

doi:10.4103/0973-1482.139338

A rare case of ALK negative CD30+ primary cutaneous anaplastic large cell lymphoma in a young adult

H. B. Sridevi, P. R. Shanthala, C. V. Raghuveer, Ananth K. Prabhu, Jallaluddin K.C. Akbar, G. S. Shivaprasad, Pooja K. Suresh, Sanjay Navani

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Cutaneous anaplastic large cell lymphoma can present either as a primary disease or as secondary to a pre-existing systemic anaplastic lymphoma. Distinguishing primary cutaneous anaplastic lymphoma (PC-ALCL) from its systemic counterpart requires a complete clinical and laboratory workup. We hereby report a case of PC-ALCL in a young adult, who presented with unusual rapidly progressive ulcerated mass in the neck. Biopsy showed anaplastic large cells, which were strongly positive for CD30 and CD25 but ALK1 gene product was negative. Clinical examination and computed tomography (CT) scan ruled out extracutaneous involvement. Chemotherapy with 6 cycles of CHOP regimen was planned and on follow-up, a complete remission of the lesion was attained.

Original language	English
Number of pages	1
Journal	Journal of Cancer Research and Therapeutics
Volume	11
Issue number	3
DOIs	https://doi.org/10.4103/0973-1482.139338
Publication status	Published - 01-01-2015

All Science Journal Classification (ASJC) codes

Oncology
Radiology Nuclear Medicine and imaging

Access to Document

10.4103/0973-1482.139338

Cite this

@article{35370d278c6643908d4ff87295a92615,

title = "A rare case of ALK negative CD30+ primary cutaneous anaplastic large cell lymphoma in a young adult",

abstract = "Cutaneous anaplastic large cell lymphoma can present either as a primary disease or as secondary to a pre-existing systemic anaplastic lymphoma. Distinguishing primary cutaneous anaplastic lymphoma (PC-ALCL) from its systemic counterpart requires a complete clinical and laboratory workup. We hereby report a case of PC-ALCL in a young adult, who presented with unusual rapidly progressive ulcerated mass in the neck. Biopsy showed anaplastic large cells, which were strongly positive for CD30 and CD25 but ALK1 gene product was negative. Clinical examination and computed tomography (CT) scan ruled out extracutaneous involvement. Chemotherapy with 6 cycles of CHOP regimen was planned and on follow-up, a complete remission of the lesion was attained.",

author = "Sridevi, {H. B.} and Shanthala, {P. R.} and Raghuveer, {C. V.} and Prabhu, {Ananth K.} and Akbar, {Jallaluddin K.C.} and Shivaprasad, {G. S.} and Suresh, {Pooja K.} and Sanjay Navani",

year = "2015",

month = jan,

day = "1",

doi = "10.4103/0973-1482.139338",

language = "English",

volume = "11",

journal = "Journal of Cancer Research and Therapeutics",

issn = "0973-1482",

publisher = "Medknow Publications and Media Pvt. Ltd",

number = "3",

}

TY - JOUR

T1 - A rare case of ALK negative CD30+ primary cutaneous anaplastic large cell lymphoma in a young adult

AU - Sridevi, H. B.

AU - Shanthala, P. R.

AU - Raghuveer, C. V.

AU - Prabhu, Ananth K.

AU - Akbar, Jallaluddin K.C.

AU - Shivaprasad, G. S.

AU - Suresh, Pooja K.

AU - Navani, Sanjay

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Cutaneous anaplastic large cell lymphoma can present either as a primary disease or as secondary to a pre-existing systemic anaplastic lymphoma. Distinguishing primary cutaneous anaplastic lymphoma (PC-ALCL) from its systemic counterpart requires a complete clinical and laboratory workup. We hereby report a case of PC-ALCL in a young adult, who presented with unusual rapidly progressive ulcerated mass in the neck. Biopsy showed anaplastic large cells, which were strongly positive for CD30 and CD25 but ALK1 gene product was negative. Clinical examination and computed tomography (CT) scan ruled out extracutaneous involvement. Chemotherapy with 6 cycles of CHOP regimen was planned and on follow-up, a complete remission of the lesion was attained.

AB - Cutaneous anaplastic large cell lymphoma can present either as a primary disease or as secondary to a pre-existing systemic anaplastic lymphoma. Distinguishing primary cutaneous anaplastic lymphoma (PC-ALCL) from its systemic counterpart requires a complete clinical and laboratory workup. We hereby report a case of PC-ALCL in a young adult, who presented with unusual rapidly progressive ulcerated mass in the neck. Biopsy showed anaplastic large cells, which were strongly positive for CD30 and CD25 but ALK1 gene product was negative. Clinical examination and computed tomography (CT) scan ruled out extracutaneous involvement. Chemotherapy with 6 cycles of CHOP regimen was planned and on follow-up, a complete remission of the lesion was attained.

UR - http://www.scopus.com/inward/record.url?scp=84945138986&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945138986&partnerID=8YFLogxK

U2 - 10.4103/0973-1482.139338

DO - 10.4103/0973-1482.139338

M3 - Article

C2 - 26458652

AN - SCOPUS:84945138986

SN - 0973-1482

VL - 11

JO - Journal of Cancer Research and Therapeutics

JF - Journal of Cancer Research and Therapeutics

IS - 3

ER -

A rare case of ALK negative CD30+ primary cutaneous anaplastic large cell lymphoma in a young adult

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this