A Review of Recent Studies on the Antioxidant and Anti-Infectious Properties of Senna Plants

Mohammed M. Alshehri, Cristina Quispe, Jesús Herrera-Bravo, Javad Sharifi-Rad, Sena Tutuncu, Elif Feyza Aydar, Cansu Topkaya, Zehra Mertdinc, Beraat Ozcelik, Mahima Aital, N. V.Anil Kumar, Natallia Lapava, Jovana Rajkovic, Andrea Ertani, Silvana Nicola, Prabhakar Semwal, Sakshi Painuli, Carlos González-Contreras, Miquel Martorell, Monica ButnariuIulia Cristina Bagiu, Radu Vasile Bagiu, Mrunal D. Barbhai, Manoj Kumar, Sevgi Durna Daştan, Daniela Calina, William C. Cho

Research output: Contribution to journalReview articlepeer-review

27 Citations (Scopus)


The use of phytochemicals is gaining interest for the treatment of metabolic syndromes over the synthetic formulation of drugs. Senna is evolving as one of the important plants which have been vastly studied for its beneficial effects. Various parts of Senna species including the root, stem, leaves, and flower are found rich in numerous phytochemicals. In vitro, in vivo, and clinical experiments established that extracts from Senna plants have diverse beneficial effects by acting as a strong antioxidant and antimicrobial agent. In this review, Senna genus is comprehensively discussed in terms of its botanical characteristics, traditional use, geographic presence, and phytochemical profile. The bioactive compound richness contributes to the biological activity of Senna plant extracts. The review emphasizes on the in vivo and in vitro antioxidant and anti-infectious properties of the Senna plant. Preclinical studies confirmed the beneficial effects of the Senna plant extracts and its bioactive components in regard to the health-promoting activities. The safety, side effects, and therapeutic limitations of the Senna plant are also discussed in this review. Additional research is necessary to utilize the phenolic compounds towards its use as an alternative to pharmacological treatments and even as an ingredient in functional foods.

Original languageEnglish
Article number6025900
Pages (from-to)6025900
Number of pages1
JournalOxidative Medicine and Cellular Longevity
Publication statusPublished - 2022

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Ageing
  • Cell Biology


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