A Review on Metal Ion Sensors Derived from Chalcone Precursor

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13 Citations (Scopus)


Disclosure of new molecular probes as chromogenic and fluorogenic cation sensors is scientifically exigent work. Recently chalcone derivatives gained more attention because of their structural variability. A suitable donor and acceptor groups separated by delocalized π-orbitals display excellent chromogenic and fluorogenic properties because of intramolecular charge transfer (ICT). These designed molecular frameworks provide the coordination sites to the incoming metal ions results in small changes in the optical properties. In a typical sensing behavior, coordination leads to a large conjugation plane with the probe resulted in hypo/hyperchromic shifts or red/blue shifts. In this review, we tried to converge the reported chalcone-derived sensors and explored the design, synthesis, metal ion sensing mechanism, and practical application of the probes. We expect that this review gives a basic outline for researchers to explore the field of chalcone-based sensors further.

Original languageEnglish
Pages (from-to)835-862
Number of pages28
JournalJournal of Fluorescence
Issue number3
Publication statusPublished - 05-2022

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Spectroscopy
  • Clinical Biochemistry


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