A Sensitive High Performance Liquid Chromatography Method for Determination of Bioequivalence of Atenolol Formulations

S. A. Shah*, I. S. Rathod, C. J. Shishoo, S. S. Savale, M. C. Satia, K. M. Bhat

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

A sensitive and specific HPLC method with fluorescence detector has been developed for the analysis of atenolol in plasma using a reverse phase column (ODS, 250 × 4.6 mm, 10 μm). Atenolol levels were measured using its excitation and emission maxima at 276 nm and 302 nm, respectively. The method has a linearity range of 50-1000 ng/ml and recovery was found to be 95.7%. This method has been successfully used for the bioequivalence study of atenolol tablets (25 mg). Cmax, tmax and AUC0-∞ of the test formulation statistically does not show significant difference from the standard formulation.

Original languageEnglish
Pages (from-to)187-192
Number of pages6
JournalIndian Journal of Pharmaceutical Sciences
Volume62
Issue number3
Publication statusPublished - 01-05-2000

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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