Abstract
A sensitive and specific HPLC method with fluorescence detector has been developed for the analysis of atenolol in plasma using a reverse phase column (ODS, 250 × 4.6 mm, 10 μm). Atenolol levels were measured using its excitation and emission maxima at 276 nm and 302 nm, respectively. The method has a linearity range of 50-1000 ng/ml and recovery was found to be 95.7%. This method has been successfully used for the bioequivalence study of atenolol tablets (25 mg). Cmax, tmax and AUC0-∞ of the test formulation statistically does not show significant difference from the standard formulation.
Original language | English |
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Pages (from-to) | 187-192 |
Number of pages | 6 |
Journal | Indian Journal of Pharmaceutical Sciences |
Volume | 62 |
Issue number | 3 |
Publication status | Published - 01-05-2000 |
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science