The purpose of this study was to test the toxicity of a Siddha drug, Sivanar Vembu Khuzhi Thailam (SVKT), in Sprague Dawley rats. The chronic toxicity study was conducted in accordance with (OECD) test guideline 408. In this study, SVKT was administered orally every day to groups 1 to 3 of rats at doses of 40, 130, and 400 mg/kg body weight for a period of 90 days. An additional satellite group (group 4) received 400 mg/kg body weight of SVKT for 90 days and did not receive the drug for another 28 days. The experiment ended on day 118 for the group 4 and day 90 for the other groups. The animals' body weight was measured once a month. Hematological and biochemical analyses were performed at the conclusion of the experiment. Histopathological examination of vital organs of rats was performed for gross findings. Organ weights were also recorded. There was no significant difference (p > 0.05) observed in the relative organs weight, body weight. However, histopathological findings seen in test groups were also seen in control. The increase in total WBC and differential counts were within normal physiological range

Original languageEnglish
Pages (from-to)88-93
Number of pages6
JournalJournal of International Dental and Medical Research
Issue number1
Publication statusPublished - 2022

All Science Journal Classification (ASJC) codes

  • Dentistry(all)


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