@article{c56fd8b4fa2f4d1f8b137316e84c5158,
title = "A toxicological evaluation of 2-dimethylaminomethyl-1-phenyl-2-propen-1-one hydrochloride",
abstract = "2-Dimethylaminomethyl-1-phenyl-2-propen-1-one hydrochloride (3) is a novel cytotoxic and anticancer agent. The objective of this study was to obtain information pertaining to possible toxic symptoms detected by in vivo evaluations in mice and an in vitro test for mutagenicity. The data obtained revealed that 3 had no effect on alanine transaminase, aspartate transaminase, HDL cholesterol and protein concentrations in sera nor were variations in the numbers of red and white blood cells detected. Furthermore autopsies of treated mice revealed no pathological symptoms in the heart, kidney, brain, spleen and testes. However elevation of the concentrations of total cholesterol, triglycerides, creatinine and urea were noted in treated mice as well as inflammation of the liver and lungs. Chromosomal aberrations were detected in a micronuclei test. In the Ames test, compound 3 was converted into one or more mutagens in the presence (but not the absence) of a murine liver homogenate. Thus future molecular modifications of 3 should bear in mind approaches to reduce or minimize unwanted side effects.",
author = "Dimmock, {J. R.} and Zello, {G. A.} and Vashishtha, {S. C.} and Hayes, {S. J.} and S. Mutalik and S. Kumar and M. Venkatesh and N. Udupa",
note = "Cited By :3 Export Date: 10 November 2017 CODEN: PHARA Correspondence Address: Dimmock, J.R.; College of Pharmacy and Nutrition, University of Sascatchewan, 110 Science Place, Saskatoon, Sask. S7N 5C9, Canada Chemicals/CAS: alanine aminotransferase, 9000-86-6, 9014-30-6; aspartate aminotransferase, 9000-97-9; creatinine, 19230-81-0, 60-27-5; urea, 57-13-6; 2-dimethylaminomethyl-1-phenyl-2-propen-1-one; Antineoplastic Agents; Cholesterol, 57-88-5; Creatinine, 60-27-5; Mannich Bases; Propiophenones; Triglycerides; Urea, 57-13-6 References: Dimmock, J.R., Kumar, P., (1997) Curr. Med. Chem., 4, p. 1; Dimmock, J.R., Shyam, K., Hamon, N.W., Logan, B.M., Raghavan, S.K., Harwood, D.J., Smith, P.J., (1983) J. Pharm. Sci., 72, p. 887; Gordon, P.M., Johnston, J.D., English, A.R., (1965) Antimicrobial Agents and Chemotherapy, p. 165. , Hobby, G. L. (Ed.): American Society for Microbiology, Bethesda; Dimmock, J.R., Raghaven, S.K., Logan, B.M., Bigam, G.E., (1983) Eur. J. Med. Chem., 18, p. 248; Baluja, G., Municio, A.M., Vega, S., (1964) Chem. and Ind., p. 2053; Benvenuto, J.A., Connor, T.H., Monteith, D.K., Laidlaw, J.L., Adams, S.C., Matney, T.S., Theiss, J.C., (1993) J. Pharm. Sci., 82, p. 988; Dimmock, J.R., Hamon, N.W., Chow, E.W.K., Kirkpatrick, D.L., Smith, L.M., Prior, M.G., (1980) Can. J. Pharm. Sci., 15, p. 84; Khachatourians, G.G., Holmlund, P.K., Dimmock, J.R., (1984) J. Pharm. Sci., 73, p. 803; Hamon, N.W., Kirkpatrick, D.L., Chow, E.W.K., Dimmock, J.R., (1982) J. Pharm. Sci., 71, p. 25; Dimmock, J.R., Kumar, P., Quail, J.W., Pugazhenthi, U., Yang, J., Chen, M., Reid, R.S., De Clercq, E., (1995) Eur. J. Med. Chem., 30, p. 209; Dimmock, J.R., Vashishtha, S.C., Patil, S.A., Udupa, N., Dinesh, S.B., Devi, P.U., Kamath, R., (1998) Pharmazie, 53, p. 702; Ames, B.N., McCann, J., Vamaski, E., (1975) Mutat. Res., 31, p. 347; Maron, D.M., Ames, B.N., (1983) Mutat. Res., 113, p. 173; Ames, B.N., Durston, W.E., Yamasaki, E., Lee, F.D., (1973) Proc. Natl. Acad. Sci. USA, 70, p. 2281; Gee, P., Maron, D.M., Ames, B.N., (1994) Proc. Natl. Acad. Sci. USA, 91, p. 11606; Hayes, S., (1988) Toxicol. Assess., 3, p. 287; Hayes, S., Gordon, A., Sadowski, I., Hayes, C., (1984) Mutat. Res., 130, p. 97; Bloom, J.C., Brandt, J.T., (2001) Casarett and Doull's Toxicology, 6. Ed., p. 402. , Klaason, C. D. (Ed.): McGraw-Hill Companies, Inc., New York; Warkany, J., (1965) Teratology: Principles and Techniques, p. 1. , Wilson, J. G.; Warkany, J. (Eds.): University of Chicago Press, Chicago; Lee, J.P., (1983) Am. J. Ind. Med., 4, p. 135; Pederson, R.A., Brandriff, B., (1980) DNA Repair and Mutagenesis in Eukaryontes, p. 389. , Generoso, W. M.; Shelby, M. D.; DeSerres, F. J. (Eds.): Plenum Press, New York; Bloom, J.C., Brandt, J.T., (2001) Casarett and Doull's Toxicology, 6. Ed., p. 393. , Klaasen, C. D. (Ed.): McGraw-Hill Companies, Inc., New York; Thomas, G., (2000) Medicinal Chemistry: An Introduction, p. 201. , John Wiley and Sons, Ltd., Chichester; Thurston, D.E., Lobo, S.G.M.J., (1998) Smith and Williams' Introduction to the Principles of Drug Design and Action, 3. Ed., p. 351. , Smith, H. J. (Ed.): Harwood Academic Publishers, Amsterdam; Dimmock, J.R., Patil, S.A., Leek, D.M., Warrington, R.C., Fang, W.D., (1987) Eur. J. Med. Chem., 22, p. 545; Wintrobe, M.M., (1961) Clinical Haematology, p. 391. , Lea and Febiger, Philadelphia; Lowry, O.H., Rosenbrough, N.J., Farr, A.I., Randall, R.J., (1951) J. Biol. Chem., 193, p. 265; Schmid, W., (1975) Mutat. Res., 31, p. 9",
year = "2003",
language = "English",
volume = "58",
pages = "136--139",
journal = "Die Pharmazie",
issn = "0031-7144",
publisher = "Govi-Verlag Pharmazeutischer Verlag GmbH",
number = "2",
}