Abstract
An attempt has been made to design suitable niosome-encapsulated drug delivery system for ciprofloxacin and norfloxacin. Encapsulation of ciprofloxacin and norfloxacin in niosomes was investigated and the nasal and intestinal absorption of the products studied. More than 80% of the drugs were successfully encapsulated to give products with sustained release characteristics. Encapsulation in niosomes also improved the stability of the antibacterial compounds. Although the systemic availability of these niosome-encapsulated antibacterial compounds was not increased after nasal administration, intestinal absorption was significantly higher in comparison with that of plain inclusion complexes.
| Original language | English |
|---|---|
| Pages (from-to) | 145-149 |
| Number of pages | 5 |
| Journal | Journal of Pharmacy and Pharmacology |
| Volume | 49 |
| Issue number | 2 |
| Publication status | Published - 02-1997 |
All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmaceutical Science