Advancement in development of antimicrobial multilayered porous-fibrous biopolymeric scaffold for wound healing application

Skin wound infections involve a significant risk of mortality and morbidity. The natural wound-healing process can be severely hampered by microbial infections, which can be extremely dangerous for human health. Tissue-engineered skin constructs are used for wound healing applications and to overcome the issues or limitations associated with the applications of autografts, allografts, and xenografts. The present review provides an extensive summary of the advancements and potential uses of the antimicrobial multilayered porous scaffold-based method for creating tissue-engineered skin constructs for wound healing. It explores the extracellular matrix of the skin and its diverse components. It delves into the process of wound healing and examines the role of antimicrobials within it. Additionally, it discusses the benefits of multilayered constructs in wound healing and highlights their successful in vivo application. Furthermore, it discusses the use of scaffolds infused with different antimicrobial agents. Finally, it concludes by addressing future prospects and considerations regarding the utilization of antimicrobial scaffolds in wound healing.