TY - JOUR
T1 - Advancement in Understanding the Concept of Epithelial to Mesenchymal Transition in Pancreatic β-Cells
T2 - Implication in Diabetes
AU - Francis, Meenal
AU - Ashok, Akshaya
AU - Ashwathnarayan, Ashwini
AU - Banerjee, Shreetama
AU - Prasan-Na, Jyothi
AU - Kumar, Anujith
N1 - Funding Information:
This work was supported by the Indian Council of Medical Research, Government of India, India (Grant No. 5/4/5-5/Diab. /20-NCD-III).
Funding Information:
The authors acknowledge the Indian Council of Medical Research, Government of India, India, for the financial support.
Publisher Copyright:
© 2023 Bentham Science Publishers.
PY - 2023
Y1 - 2023
N2 - Distinct molecular processes are engaged during histogenesis, and Epithelial to Mesen-chymal Transition (EMT) is one of the key evolutionarily conserved processes that facilitates organ development. Molecular pathways governing EMT are embedded within developmental programs and operate in cells of different tissues. Among varied cell types, EMT in pancreatic β-cells is of greater interest as the existence of EMT in these cells is highly debated. Although in vitro generation of human islet-derived mesenchymal progenitor cells has been proven beyond doubt, the existence of EMT in pancreatic β-cells in vivo remains enigmatic. Understanding the in-depth process of EMT in in vivo human β-cells is challenged by the limitations of lineage-tracing studies, which are otherwise feasible in mice. Exploring EMT of β-cells would greatly facilitate the generation of clin-ically relevant β-cells either by enhancing long-term in vitro culture of endogenous islets or by differentiation of pluripotent stem cells to mature β-cells. This review is an update on the recent pro-gress in understanding the EMT process of β-cells and how the investigations have helped to resolve the mystery of the existence of EMT in pancreatic β-cells.
AB - Distinct molecular processes are engaged during histogenesis, and Epithelial to Mesen-chymal Transition (EMT) is one of the key evolutionarily conserved processes that facilitates organ development. Molecular pathways governing EMT are embedded within developmental programs and operate in cells of different tissues. Among varied cell types, EMT in pancreatic β-cells is of greater interest as the existence of EMT in these cells is highly debated. Although in vitro generation of human islet-derived mesenchymal progenitor cells has been proven beyond doubt, the existence of EMT in pancreatic β-cells in vivo remains enigmatic. Understanding the in-depth process of EMT in in vivo human β-cells is challenged by the limitations of lineage-tracing studies, which are otherwise feasible in mice. Exploring EMT of β-cells would greatly facilitate the generation of clin-ically relevant β-cells either by enhancing long-term in vitro culture of endogenous islets or by differentiation of pluripotent stem cells to mature β-cells. This review is an update on the recent pro-gress in understanding the EMT process of β-cells and how the investigations have helped to resolve the mystery of the existence of EMT in pancreatic β-cells.
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U2 - 10.2174/1573399818666220519143414
DO - 10.2174/1573399818666220519143414
M3 - Review article
C2 - 35598235
AN - SCOPUS:85153851029
SN - 1573-3998
VL - 19
SP - 92
EP - 108
JO - Current Diabetes Reviews
JF - Current Diabetes Reviews
IS - 6
M1 - e190522205030
ER -
