Advancements in cell membrane camouflaged nanoparticles: A bioinspired platform for cancer therapy

Namdev Dhas, Mónica C. García, Ritu Kudarha, Abhijeet Pandey, Ajinkya Nitin Nikam, Divya Gopalan, Gasper Fernandes, Soji Soman, Sanjay Kulkarni, Raviraja N. Seetharam, Ruchi Tiwari, Sarika Wairkar, Chandrakantsing Pardeshi, Srinivas Mutalik

Research output: Contribution to journalReview articlepeer-review

45 Citations (Scopus)


The idea of employing natural cell membranes as a coating medium for nanoparticles (NPs) endows man-made vectors with natural capabilities and benefits. In addition to retaining the physicochemical characteristics of the NPs, the biomimetic NPs also have the functionality of source cell membranes. It has emerged as a promising approach to enhancing the properties of NPs for drug delivery, immune evasion, imaging, cancer-targeting, and phototherapy sensitivity. Several studies have been reported with a multitude of approaches to reengineering the surface of NPs using biological membranes. Owing to their low immunogenicity and intriguing biomimetic properties, cell-membrane-based biohybrid delivery systems have recently gained a lot of interest as therapeutic delivery systems. This review summarises different kinds of biomimetic NPs reported so far, their fabrication aspects, and their application in the biomedical field. Finally, it briefs on the latest advances available in this biohybrid concept.

Original languageEnglish
Pages (from-to)71-97
Number of pages27
JournalJournal of Controlled Release
Publication statusPublished - 06-2022

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science


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