TY - JOUR
T1 - Advancements in cell membrane camouflaged nanoparticles
T2 - A bioinspired platform for cancer therapy
AU - Dhas, Namdev
AU - García, Mónica C.
AU - Kudarha, Ritu
AU - Pandey, Abhijeet
AU - Nikam, Ajinkya Nitin
AU - Gopalan, Divya
AU - Fernandes, Gasper
AU - Soman, Soji
AU - Kulkarni, Sanjay
AU - Seetharam, Raviraja N.
AU - Tiwari, Ruchi
AU - Wairkar, Sarika
AU - Pardeshi, Chandrakantsing
AU - Mutalik, Srinivas
N1 - Funding Information:
The authors thank the Department of Science and Technology (DST), Government of India, New Delhi, for funding the research project and the Senior Research Fellowship to Dr. Ritu Kudarha. The authors are also grateful to the Board of Research in Nuclear Science (BRNS), the Department of Atomic Energy (DAE), the Government of India for funding the research project and the Junior Research Fellowship to Sanjay Kulkarni. The authors are thankful to i) Manipal Academy of Higher Education (MAHE), Manipal, for providing Dr. TMA Pai Doctoral Scholarship to Ajinkya Nitin Nikam and Gasper Fernandes and ii) Department of Science and Technology (DST), Government of India, New Delhi for providing INSPIRE fellowship to Soji Soman and iii) Indian Council of Medical Research, Government India, New Delhi for providing Senior Research Fellowship to Divya Gopalan. The authors thank Manipal College of Pharmaceutical Sciences and MAHE, Manipal, India, for providing the necessary facilities. García MC is a member of CONICET scientific career. The author acknowledges the assistance of the CONICET and the Universidad Nacional de Cordoba (UNC), both of which provided facilities for this work.
Funding Information:
The authors thank the Department of Science and Technology (DST), Government of India, New Delhi, for funding the research project and the Senior Research Fellowship to Dr. Ritu Kudarha. The authors are also grateful to the Board of Research in Nuclear Science (BRNS), the Department of Atomic Energy (DAE), the Government of India for funding the research project and the Junior Research Fellowship to Sanjay Kulkarni. The authors are thankful to i) Manipal Academy of Higher Education (MAHE), Manipal, for providing Dr. TMA Pai Doctoral Scholarship to Ajinkya Nitin Nikam and Gasper Fernandes and ii) Department of Science and Technology (DST), Government of India, New Delhi for providing INSPIRE fellowship to Soji Soman and iii) Indian Council of Medical Research, Government India, New Delhi for providing Senior Research Fellowship to Divya Gopalan. The authors thank Manipal College of Pharmaceutical Sciences and MAHE, Manipal, India, for providing the necessary facilities. Garc?a MC is a member of CONICET scientific career. The author acknowledges the assistance of the CONICET and the Universidad Nacional de Cordoba (UNC), both of which provided facilities for this work.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/6
Y1 - 2022/6
N2 - The idea of employing natural cell membranes as a coating medium for nanoparticles (NPs) endows man-made vectors with natural capabilities and benefits. In addition to retaining the physicochemical characteristics of the NPs, the biomimetic NPs also have the functionality of source cell membranes. It has emerged as a promising approach to enhancing the properties of NPs for drug delivery, immune evasion, imaging, cancer-targeting, and phototherapy sensitivity. Several studies have been reported with a multitude of approaches to reengineering the surface of NPs using biological membranes. Owing to their low immunogenicity and intriguing biomimetic properties, cell-membrane-based biohybrid delivery systems have recently gained a lot of interest as therapeutic delivery systems. This review summarises different kinds of biomimetic NPs reported so far, their fabrication aspects, and their application in the biomedical field. Finally, it briefs on the latest advances available in this biohybrid concept.
AB - The idea of employing natural cell membranes as a coating medium for nanoparticles (NPs) endows man-made vectors with natural capabilities and benefits. In addition to retaining the physicochemical characteristics of the NPs, the biomimetic NPs also have the functionality of source cell membranes. It has emerged as a promising approach to enhancing the properties of NPs for drug delivery, immune evasion, imaging, cancer-targeting, and phototherapy sensitivity. Several studies have been reported with a multitude of approaches to reengineering the surface of NPs using biological membranes. Owing to their low immunogenicity and intriguing biomimetic properties, cell-membrane-based biohybrid delivery systems have recently gained a lot of interest as therapeutic delivery systems. This review summarises different kinds of biomimetic NPs reported so far, their fabrication aspects, and their application in the biomedical field. Finally, it briefs on the latest advances available in this biohybrid concept.
UR - http://www.scopus.com/inward/record.url?scp=85128705242&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85128705242&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2022.04.019
DO - 10.1016/j.jconrel.2022.04.019
M3 - Review article
C2 - 35439581
AN - SCOPUS:85128705242
SN - 0168-3659
VL - 346
SP - 71
EP - 97
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -
