Age related changes in lipid peroxidation and antioxidants in elderly people

Akila V. Prashant; H. Harishchandra; Vivian D'Souza; Benedicta D'Souza

doi:10.1007/BF02912896

Age related changes in lipid peroxidation and antioxidants in elderly people

Akila V. Prashant, H. Harishchandra, Vivian D'Souza, Benedicta D'Souza

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Advanced age is associated with an accumulation of free radical damage, which leads to physiological and clinical modifications. Age related changes resulting from free radical reactions include increasing levels of lipid peroxides, alterations in enzyme activities and greater osmotic fragility. The present study was conducted to estimate the level of lipid peroxidation product - Malondialdehyde and antioxidants Catalase and Glutathione in elderly people. An increase in lipid peroxidation and decrease in antioxidants was observed in normal elderly people. Highly significant increase in MDA and decrease in antioxidants was observed in elderly people when complicated with diabetes and hypertension. Supplementation of antioxidants may prevent further oxidative injury in elderly people.

Original language	English
Pages (from-to)	131-134
Number of pages	4
Journal	Indian Journal of Clinical Biochemistry
Volume	22
Issue number	1
DOIs	https://doi.org/10.1007/BF02912896
Publication status	Published - 19-03-2007
Externally published	Yes

All Science Journal Classification (ASJC) codes

Clinical Biochemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF02912896

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AU - D'Souza, Vivian

AU - D'Souza, Benedicta

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N2 - Advanced age is associated with an accumulation of free radical damage, which leads to physiological and clinical modifications. Age related changes resulting from free radical reactions include increasing levels of lipid peroxides, alterations in enzyme activities and greater osmotic fragility. The present study was conducted to estimate the level of lipid peroxidation product - Malondialdehyde and antioxidants Catalase and Glutathione in elderly people. An increase in lipid peroxidation and decrease in antioxidants was observed in normal elderly people. Highly significant increase in MDA and decrease in antioxidants was observed in elderly people when complicated with diabetes and hypertension. Supplementation of antioxidants may prevent further oxidative injury in elderly people.

AB - Advanced age is associated with an accumulation of free radical damage, which leads to physiological and clinical modifications. Age related changes resulting from free radical reactions include increasing levels of lipid peroxides, alterations in enzyme activities and greater osmotic fragility. The present study was conducted to estimate the level of lipid peroxidation product - Malondialdehyde and antioxidants Catalase and Glutathione in elderly people. An increase in lipid peroxidation and decrease in antioxidants was observed in normal elderly people. Highly significant increase in MDA and decrease in antioxidants was observed in elderly people when complicated with diabetes and hypertension. Supplementation of antioxidants may prevent further oxidative injury in elderly people.

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Age related changes in lipid peroxidation and antioxidants in elderly people

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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