TY - GEN
T1 - Alpha-amylase activity of tannin isolated from Terminalia chebula
AU - Mukherjee, Sutapa
AU - Mitra, Analava
AU - Dey, Satyahari
AU - Thakur, Goutam
PY - 2010/12/1
Y1 - 2010/12/1
N2 - One important therapeutic approach for the treatment of Type 2 Diabetes Mellitus is by decreasing the postprandial increase of glucose. This is possible by inhibiting certain carbohydrate hydrolyzing enzymes like alpha-amylase. In the present study, the inhibitory effect of tannins isolated from the alcoholic extract of fruits of Terminalia chebula was evaluated for the first time with porcine pancreatic amylase and potato starch as substrate. The result indicated that highest inhibition (52%) was obtained at the concentration of 100g/ml of tannins extracted from the fruits. The result was comparable to that of Acarbose which is a very effective antidiabetic agent.
AB - One important therapeutic approach for the treatment of Type 2 Diabetes Mellitus is by decreasing the postprandial increase of glucose. This is possible by inhibiting certain carbohydrate hydrolyzing enzymes like alpha-amylase. In the present study, the inhibitory effect of tannins isolated from the alcoholic extract of fruits of Terminalia chebula was evaluated for the first time with porcine pancreatic amylase and potato starch as substrate. The result indicated that highest inhibition (52%) was obtained at the concentration of 100g/ml of tannins extracted from the fruits. The result was comparable to that of Acarbose which is a very effective antidiabetic agent.
UR - https://www.scopus.com/pages/publications/79955691345
UR - https://www.scopus.com/pages/publications/79955691345#tab=citedBy
U2 - 10.1109/ICSMB.2010.5735421
DO - 10.1109/ICSMB.2010.5735421
M3 - Conference contribution
AN - SCOPUS:79955691345
SN - 9781612840383
T3 - International Conference on Systems in Medicine and Biology, ICSMB 2010 - Proceedings
SP - 443
EP - 445
BT - International Conference on Systems in Medicine and Biology, ICSMB 2010 - Proceedings
T2 - International Conference on Systems in Medicine and Biology, ICSMB 2010
Y2 - 16 December 2010 through 18 December 2010
ER -
