Alterations induced by Bisphenol A on cellular organelles and potential relevance on human health

Nadeem G. Khan, Bushra Tungekar, Divya Adiga, Sanjiban Chakrabarty, Padmalatha S. Rai, Shama Prasada Kabekkodu

Research output: Contribution to journalReview articlepeer-review


Bisphenol A (BPA) is a chemical partially soluble in water and exists in a solid state. Its structural similarity with estrogen makes it an endocrine-disrupting chemical. BPA can disrupt signaling pathways at very low doses and may cause organellar stress. According to in vitro and in vivo studies, BPA interacts with various cell surface receptors to cause organellar stress, producing free radicals, cellular toxicity, structural changes, DNA damage, mitochondrial dysfunction, cytoskeleton remodeling, centriole duplication, and aberrant changes in several cell signaling pathways. The current review summarizes the impact of BPA exposure on the structural and functional aspects of subcellular components of cells such as the nucleus, mitochondria, endoplasmic reticulum, lysosome, ribosome, Golgi apparatus, and microtubules and its consequent impact on human health.

Original languageEnglish
Article number119505
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Issue number7
Publication statusPublished - 10-2023

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology


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