TY - JOUR
T1 - Alterations induced by Bisphenol A on cellular organelles and potential relevance on human health
AU - Khan, Nadeem G.
AU - Tungekar, Bushra
AU - Adiga, Divya
AU - Chakrabarty, Sanjiban
AU - Rai, Padmalatha S.
AU - Kabekkodu, Shama Prasada
N1 - Funding Information:
We acknowledge the Directorate of Minorities Fellowship for Minority Students (DOM/FELLOWSHIP/CR-10/2019-20), Government of Karnataka; ICMR-Senior Research fellowship (Reference ID-2019/4115/CMB/BMS), Government of India, and Dr. TMA Pai Structured Ph.D. fellowship from Manipal Academy of Higher Education (MAHE). All the authors thank Manipal Academy of Higher Education, Manipal, Technology Information Forecasting and Assessment Council (TIFAC)-Core in Pharmacogenomics at MAHE, Manipal, Fund for Improvement of S&T Infrastructure (FIST) and Karnataka Fund for Infrastructure Strengthening in Science and Technology (K-FIST), Government of Karnataka.
Funding Information:
We acknowledge the Directorate of Minorities Fellowship for Minority Students ( DOM/FELLOWSHIP/CR-10/2019-20 ), Government of Karnataka; ICMR -Senior Research fellowship (Reference ID-2019/4115/CMB/BMS ), Government of India, and Dr. TMA Pai Structured Ph.D. fellowship from Manipal Academy of Higher Education (MAHE). All the authors thank Manipal Academy of Higher Education, Manipal, Technology Information Forecasting and Assessment Council (TIFAC)-Core in Pharmacogenomics at MAHE, Manipal, Fund for Improvement of S&T Infrastructure (FIST) and Karnataka Fund for Infrastructure Strengthening in Science and Technology (K-FIST), Government of Karnataka.
Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/10
Y1 - 2023/10
N2 - Bisphenol A (BPA) is a chemical partially soluble in water and exists in a solid state. Its structural similarity with estrogen makes it an endocrine-disrupting chemical. BPA can disrupt signaling pathways at very low doses and may cause organellar stress. According to in vitro and in vivo studies, BPA interacts with various cell surface receptors to cause organellar stress, producing free radicals, cellular toxicity, structural changes, DNA damage, mitochondrial dysfunction, cytoskeleton remodeling, centriole duplication, and aberrant changes in several cell signaling pathways. The current review summarizes the impact of BPA exposure on the structural and functional aspects of subcellular components of cells such as the nucleus, mitochondria, endoplasmic reticulum, lysosome, ribosome, Golgi apparatus, and microtubules and its consequent impact on human health.
AB - Bisphenol A (BPA) is a chemical partially soluble in water and exists in a solid state. Its structural similarity with estrogen makes it an endocrine-disrupting chemical. BPA can disrupt signaling pathways at very low doses and may cause organellar stress. According to in vitro and in vivo studies, BPA interacts with various cell surface receptors to cause organellar stress, producing free radicals, cellular toxicity, structural changes, DNA damage, mitochondrial dysfunction, cytoskeleton remodeling, centriole duplication, and aberrant changes in several cell signaling pathways. The current review summarizes the impact of BPA exposure on the structural and functional aspects of subcellular components of cells such as the nucleus, mitochondria, endoplasmic reticulum, lysosome, ribosome, Golgi apparatus, and microtubules and its consequent impact on human health.
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U2 - 10.1016/j.bbamcr.2023.119505
DO - 10.1016/j.bbamcr.2023.119505
M3 - Review article
C2 - 37286138
AN - SCOPUS:85163066602
SN - 0167-4889
VL - 1870
JO - Biochimica et Biophysica Acta - Molecular Cell Research
JF - Biochimica et Biophysica Acta - Molecular Cell Research
IS - 7
M1 - 119505
ER -
