Alternative markers of glycemic status in diabetes mellitus

Anupama Hegde, Ramya Shenoy, Prajwal D'Mello, A. Smitha, A. Tintu, Poornima Manjrekar

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Monitoring people with diabetes by repeatedly estimating blood glucose and glycosylated hemoglobin levels is invasive which becomes appalling and expensive over time. Potential of saliva as a diagnostic tool could be exploited in this regard. 26 diabetes patients were com-pared with 21 age matched non-diabetic healthy controls for Fasting plasma glucose (FPG), salivary glucose (SG), salivary pH (SpH), Oral health status and markers of oxidative stress in saliva namely Thiobarbituric Acid Reactive substance (TBARS) or Malondialdehyde (MDA) and Total antioxidant activity (AOA). Significantly high FPG (p=0.005) along with high salivary AOA (p < 0.0001) levels, markedly lesser SpH and MDA were found in the di-abetic group. Changes in SG levels between the groups were of no consequence. FPG showed positive correlation to SG (r = 0.410) and even better correlation with salivary MDA (r = 0.562) only in diabetes. Since SG levels did not differ between the two groups, the study concludes that conventional marker like FPG is a better indicator of glycemic status. Lower MDA seen in saliva of diabetic group may be probably due to the exceptionally high AOA activity seen in these people.

Original languageEnglish
Pages (from-to)252-256
Number of pages5
JournalBiomedical Research
Issue number3
Publication statusPublished - 2010

All Science Journal Classification (ASJC) codes

  • General Medicine
  • General Biochemistry,Genetics and Molecular Biology


Dive into the research topics of 'Alternative markers of glycemic status in diabetes mellitus'. Together they form a unique fingerprint.

Cite this