Amelanotic Mucosal Melanoma of the Nasal Cavity

Mucosal melanomas are rare head-and-neck tumors and have a distinct etiology and genetic profile different from cutaneous counterparts. They are most commonly seen in sixth-seventh decade of life and have aggressive behavior. The patients usually present with nodal metastasis, which is the most important poor prognostic indicator for mucosal melanomas. We present a case of mucosal melanomas in a young male (30 years), who presented with nonpigmented, polypoidal mass in the right nasal cavity simulating an inverted papilloma. Histological examination showed small to large pleomorphic cells and no melanin pigment. Based on the immunopositivity of the tumour cells were positive for HMB45 and S100 confirming a diagnosis of amelanotic mucosal melanoma. The partied had a localized disease to the right nasal cavity with no nodal involvement and no recurrences in the available follow-up of 24 months.