Ameliorative effect of caffeic acid against inflammatory pain in rodents

Anurag Mehrotra, Ravindranath Shanbhag, Mallikarjuna Rao Chamallamudi, Vijay Pal Singh, Jayesh Mudgal

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)


The present study was designed to evaluate the antinociceptive profile of caffeic acid in mice and rats. Caffeic acid (5-100 mg/kg, p.o.), in a dose dependent manner inhibited acetic acid-induced writhing and late phase of formalin-induced pain in mice, with an ED50 of 22.38 and 10.92 mg/kg, respectively. However, caffeic acid was ineffective in the hot plate and tail flick tests. Analgesic activity was also examined in carrageenan and lipopolysaccharide (LPS)-induced mechanical hyperalgesia in rats, where locally induced myeloperoxidase (MPO), malondialdehyde (MDA) and nitrite levels in foot pad were estimated by colorimetric assay. Oral administration of caffeic acid (200 mg/kg, p.o.) showed analgesic activity similar to nimesulide (4 mg/kg, p.o.) and inhibited MPO, MDA and nitrite generation in the inflamed paw. Histological examination revealed reduction in neutrophil infiltration and protection of tissue damage by caffeic acid. These results suggest that caffeic acid exhibits peripheral analgesic effect in mice and rats and could be further examined for the treatment of chronic painful episodes.

Original languageEnglish
Pages (from-to)80-86
Number of pages7
JournalEuropean Journal of Pharmacology
Issue number1-3
Publication statusPublished - 09-2011

All Science Journal Classification (ASJC) codes

  • Pharmacology


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