TY - JOUR
T1 - An insight into the role of cyclooxygenase and lipooxygenase pathway in renal ischemia
AU - Kinra, M.
AU - Mudgal, J.
AU - Arora, D.
AU - Nampoothiri, M.
N1 - Publisher Copyright:
© 2017 Verduci Editore s.r.l. All rights reserved.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - OBJECTIVE: Renal ischemia (RI) is a clinical condition that occurs due to marked decrease in renal blood flow. The pathophysiology of RI is interlinked with atherosclerotic renal artery stenosis, infarction, organ transplantation and sepsis. The mechanism of RI injury depends on various factors such as inflammatory response, oxidative stress and apoptosis. In this review, we evaluate the role of cyclooxygenase and lipoxygenase in modulating the process of ischemic renal injury. MATERIALS AND METHODS: This is a literature review of articles published on PubMed and Web of Science in English. RESULTS: RI is characterized by an inflammatory response and oxidative stress, which are further worsened by the metabolites of the arachidonic acid pathway. CONCLUSIONS: RI results from a vigorous process involving inflammation and some mediators in a multifaceted interaction. Indulgence of oxidative stress and lipid peroxidation seems to be major factors which promote the inflammation process during RI.
AB - OBJECTIVE: Renal ischemia (RI) is a clinical condition that occurs due to marked decrease in renal blood flow. The pathophysiology of RI is interlinked with atherosclerotic renal artery stenosis, infarction, organ transplantation and sepsis. The mechanism of RI injury depends on various factors such as inflammatory response, oxidative stress and apoptosis. In this review, we evaluate the role of cyclooxygenase and lipoxygenase in modulating the process of ischemic renal injury. MATERIALS AND METHODS: This is a literature review of articles published on PubMed and Web of Science in English. RESULTS: RI is characterized by an inflammatory response and oxidative stress, which are further worsened by the metabolites of the arachidonic acid pathway. CONCLUSIONS: RI results from a vigorous process involving inflammation and some mediators in a multifaceted interaction. Indulgence of oxidative stress and lipid peroxidation seems to be major factors which promote the inflammation process during RI.
UR - https://www.scopus.com/pages/publications/85048410575
UR - https://www.scopus.com/inward/citedby.url?scp=85048410575&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85048410575
SN - 1128-3602
VL - 21
SP - 5017
EP - 5020
JO - European Review for Medical and Pharmacological Sciences
JF - European Review for Medical and Pharmacological Sciences
IS - 21
ER -