TY - JOUR
T1 - An intraocular lens-based biodegradable drug delivery system for the treatment of post-cataract inflammation
AU - Pinto, Joyce
AU - Addoor, Krishna Rao
AU - Guru, Bharath Raja
N1 - Funding Information:
This research was supported by Vision Group on Science and Technology (VGST), Karnataka Fund for Improvement of Science and Technology Infrastructure (K-FIST) funded by Department of Information Technology, Biotechnology & Science and Technology, Government of Karnataka, India. We also extend our heartfelt gratitude towards Symbiotec Pharmalab Pvt. Ltd. Indore, India for donating Dexamethasone for our research.
Publisher Copyright:
© (2021) Society for Biomaterials & Artificial Organs #20053321
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Prolonged inflammation after post cataract surgery causes inconvenience in patients. Inadequate treatment results in loss of vision to around 30000 patients/year in India. Currently, treatment is topical administration of eye drops. We propose a biodegradable drug delivery system (DDS) bound to intraocular lens (IOL) haptic which combines surgery and post-operative care. To overcome the disadvantages of topical administration the polymer poly lactic-co-glycolic acid (PLGA) is designed as a thin film strip with Dexamethasone (DEX) to release therapeutic amount of drug over a period of 4 to 6 weeks. The study involved two PLGA co-polymer ratios 75:25 and 50:50 with different polymer:drug ratios were used to study the release of drug over a period of 30 days. PLGA75:25 (dimensions: 30x3mm; thickness 0.073mm) loaded with 158μg DEX released around 3.5μg in the first 5 days and then 0.52μg/day for remaining 25 days. The DDS was characterized by Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD) and Differential Scanning Colorimetry (DSC). In vitro drug release kinetics were mathematically modelled using zero order, first order, Higuchi, Korsmeyer-Peppas and Hixson Crowell model and then fit to experimental data. Korsmeyer-Peppas model and Higuchi model best fit the experimental data.
AB - Prolonged inflammation after post cataract surgery causes inconvenience in patients. Inadequate treatment results in loss of vision to around 30000 patients/year in India. Currently, treatment is topical administration of eye drops. We propose a biodegradable drug delivery system (DDS) bound to intraocular lens (IOL) haptic which combines surgery and post-operative care. To overcome the disadvantages of topical administration the polymer poly lactic-co-glycolic acid (PLGA) is designed as a thin film strip with Dexamethasone (DEX) to release therapeutic amount of drug over a period of 4 to 6 weeks. The study involved two PLGA co-polymer ratios 75:25 and 50:50 with different polymer:drug ratios were used to study the release of drug over a period of 30 days. PLGA75:25 (dimensions: 30x3mm; thickness 0.073mm) loaded with 158μg DEX released around 3.5μg in the first 5 days and then 0.52μg/day for remaining 25 days. The DDS was characterized by Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD) and Differential Scanning Colorimetry (DSC). In vitro drug release kinetics were mathematically modelled using zero order, first order, Higuchi, Korsmeyer-Peppas and Hixson Crowell model and then fit to experimental data. Korsmeyer-Peppas model and Higuchi model best fit the experimental data.
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M3 - Article
AN - SCOPUS:85119605258
SN - 0971-1198
VL - 35
SP - 415
EP - 423
JO - Trends in Biomaterials and Artificial Organs
JF - Trends in Biomaterials and Artificial Organs
IS - 5
ER -