An overview of the current advances in the treatment of inflammatory diseases using mesenchymal stromal cell secretome

Jahnavy Madhukar Joshi, Manjunatha S. Muttigi, Raghavendra Upadhya, Raviraja N. Seetharam

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

The growing interest in mesenchymal stromal cell (MSC) therapy has been leading to the utilization of its therapeutic properties in a variety of inflammatory diseases. The clinical translation of the related research from bench to bedside is cumbersome due to some obvious limitations of cell therapy. It is evident from the literature that the MSC secretome components mediate their wide range of functions. Cell-free therapy using MSC secretome is being considered as an emerging and promising area of biotherapeutics. The secretome mainly consists of bioactive factors, free nucleic acids, and extracellular vesicles. Constituents of the secretome are greatly influenced by the cell’s microenvironment. The broad array of immunomodulatory properties of MSCs are now being employed to target inflammatory diseases. This review focuses on the emerging MSC secretome therapies for various inflammatory diseases. The mechanism of action of the various anti-inflammatory factors is discussed. The potential of MSC secretome as a viable anti-inflammatory therapy is deliberated.

Original languageEnglish
Pages (from-to)497-507
Number of pages11
JournalImmunopharmacology and Immunotoxicology
Volume45
Issue number4
DOIs
Publication statusPublished - 2023

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Toxicology
  • Pharmacology

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