Analgesic and antiinflammatory activity of leaf extracts of Commiphora caudata in rodents

The present study was undertaken to evaluate the analgesic and anti-inflammatory activity of Alcoholic (70%) and Aqueos extracts of leaves of Commiphora caudata in rodents. The dried powder of the leaves was initially extracted with 70% Alcoholic (ALCC) and Water (AQCC) successively. Acute oral toxicity of ALCC and AQCC were conducted as per OECD guidelines 425. Acute toxicity studies revealed that both the extracts are safe upto 2000mg/kg.The extracts were evaluated for Analgesic activity with formalin induced paw licking test in mice using Pentazocin (2mg/kg,i.p.) as a standard and Anti-inflammatory activity was evaluated with carrageenan induced rat paw edema model in wistar rats using Diclofenac (15mg/kg,i.p) a standard. Acute toxicity results have revealed that both ALCC and AQCC were safe upto 2000 mg/kg dose. In formalin induced paw licking test ALCC at 100, 200 and 400mg/kg, AQCC at 200 and 400mg/kg have showed significant inhibition of paw licking in both early and late phase of the formalin test when compare to control group; In carrageenan induced rat paw edema model ALCC at 200 and 400mg/ kg, AQCC at 400mg/kg have showed significant inhibition in carrageenan induced rat paw when compare to control group, these observations suggests that ALCC and AQCC possess good analgesic and antiinflammatory activity but the Alcoholic is more potent when compare to Aqueous extract.