TY - JOUR
T1 - Angiogenesis in cutaneous lesions of leprosy
T2 - Implications for treatment
AU - Bhandarkar, Sulochana S.
AU - Cohen, Cynthia
AU - Kuruvila, Maria
AU - Rea, Thomas H.
AU - MacKelfresh, Jamie B.
AU - Lee, Delphine J.
AU - Modlin, Robert L.
AU - Arbiser, Jack L.
PY - 2007/12/1
Y1 - 2007/12/1
N2 - Objective: To examine the potential role of angiogenesis in leprosy. Design: Immunohistochemical analysis of leprosy lesions. Setting: Department of Dermatology, Venereology, and Leprology, Kasturba Medical College; Division of Dermatology, University of California at Los Angeles; and Departments of Dermatology and Pathology, Emory University. Patients: Thirty-two cutaneous lesions that represented the spectrum of leprosy were obtained from 32 patients. Main Outcome Measure: CD31 microvessel counts. Results: The mean CD31 microvessel count in borderline tuberculoid, midborderline, and lepromatous leprosy lesions was significantly higher than in indeterminate leprosy lesions. Conclusions: Increased bacterial load is associated with increased angiogenesis. Angiogenesis inhibitors may be of benefit in the treatment of leprosy.
AB - Objective: To examine the potential role of angiogenesis in leprosy. Design: Immunohistochemical analysis of leprosy lesions. Setting: Department of Dermatology, Venereology, and Leprology, Kasturba Medical College; Division of Dermatology, University of California at Los Angeles; and Departments of Dermatology and Pathology, Emory University. Patients: Thirty-two cutaneous lesions that represented the spectrum of leprosy were obtained from 32 patients. Main Outcome Measure: CD31 microvessel counts. Results: The mean CD31 microvessel count in borderline tuberculoid, midborderline, and lepromatous leprosy lesions was significantly higher than in indeterminate leprosy lesions. Conclusions: Increased bacterial load is associated with increased angiogenesis. Angiogenesis inhibitors may be of benefit in the treatment of leprosy.
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U2 - 10.1001/archderm.143.12.1527
DO - 10.1001/archderm.143.12.1527
M3 - Article
C2 - 18087002
AN - SCOPUS:37249041613
SN - 2168-6068
VL - 143
SP - 1527
EP - 1529
JO - JAMA Dermatology
JF - JAMA Dermatology
IS - 12
ER -