Anthelmintic and antibacterial screening of a new series of N-[4-(4-nitrophenoxy)phenyl]-4-(substituted)-1,3-thiazol-2-amines

Namratha Bhandari, Santosh L. Gaonkar

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


A series of N-[4-(4-nitrophenoxy)phenyl]-4-(substituted)-1,3-thiazol-2-amines was synthesized. Structural elucidation was accomplished by 1H NMR, 13C NMR, IR, and elemental analyses of synthesized compounds. The title compounds were derived from 4-(4-nitrophenoxy)phenyl thiourea, which is the key intermediate in the synthesis of nitroscanate, an anthelmintic drug. Among the synthesized compounds, N-[4-(4-nitrophenoxy)phenyl]-4-(4-fluorophenyl)-1,3-thiazol-2-amine and N-[4-(4-nitrophenoxy)phenyl]-4-(4-methoxyphenyl)-1,3-thiazol-2-amine exhibited potent anthelmintic and antibacterial activities.

Original languageEnglish
Pages (from-to)210-214
Number of pages5
JournalRussian Journal of Bioorganic Chemistry
Issue number2
Publication statusPublished - 01-03-2016

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry


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