TY - JOUR
T1 - Anti-hyperglycemic, anti-hyperlipidemic, and anti-inflammatory effect of the drug Guggulutiktaka ghrita on high-fat diet-induced obese rats
AU - Sheik, Samreen M.
AU - Bakthavatchalam, Pugazhandhi
AU - Shenoy, Revathi P.
AU - Hadapad, Basavaraj S.
AU - Nayak M, Deepak
AU - Biswas, Monalisa
AU - Bolar Suryakanth, Varashree
N1 - Funding Information:
The authors greatly acknowledge the management of Kasturba Medical College, Manipal the Manipal Academy of Higher Education for providing us the platform, infrastructure, and encouragement for our research Weactivities. We also acknowledge the Directorate of Research, Manipal Academy of Higher Education (MAHE) to provide us with the intramural seed funding (ID 00000031) which aided us to complete the project.
Funding Information:
Intramural Faculty Seed grant by the Directorate of Research, Manipal Academy of Higher Education (MAHE) (ID 00000031).
Publisher Copyright:
© 2022 The Authors
PY - 2022/7/1
Y1 - 2022/7/1
N2 - Background: Ayurveda is a holistic system of medicine and describes a vast array of herbs and herbal mixtures that are been demonstrated to possess efficacy in research investigations. Guggulutikthaka gritha (GTG) is one such drug evaluated for its role in skin and bone diseases. Objective: In the current study, the hypoglycemic, hypolipidemic, and anti-inflammatory effect of the drug GTG was studied with the scope to treat dyslipidemia and thereby reduce the risk of cardiovascular disease. Materials and method: The animals (Wistar rats) were fed a high-fat diet and dyslipidemia was induced. The control group was provided with a normal chow diet and had free access to water. The treatment with the drug GTG was given for 21 days after confirming dyslipidemia. The blood glucose was measured immediately using a glucometer. The serum was analyzed for lipid profile and Vascular Cell Adhesion Molecule – 1(VCAM 1) by ELISA method before and after treatment. The histopathology of the heart and liver was also performed. Results: The abnormal change in lipid profile, blood glucose, and inflammatory marker along with the accumulation of intracellular fats in the arteries of the heart and liver confirmed dyslipidemia. A significant reduction in serum lipid profile (p < 0.05), blood glucose (p < 0.05), and VCAM 1 (p < 0.05) was noted after the treatment with significant histopathological changes in arteries of the heart and liver. Conclusion: The study provides scientific validation on the drug GTG being effective in hyperglycemia, hyperlipidemia, and inflammation in dyslipidemia.
AB - Background: Ayurveda is a holistic system of medicine and describes a vast array of herbs and herbal mixtures that are been demonstrated to possess efficacy in research investigations. Guggulutikthaka gritha (GTG) is one such drug evaluated for its role in skin and bone diseases. Objective: In the current study, the hypoglycemic, hypolipidemic, and anti-inflammatory effect of the drug GTG was studied with the scope to treat dyslipidemia and thereby reduce the risk of cardiovascular disease. Materials and method: The animals (Wistar rats) were fed a high-fat diet and dyslipidemia was induced. The control group was provided with a normal chow diet and had free access to water. The treatment with the drug GTG was given for 21 days after confirming dyslipidemia. The blood glucose was measured immediately using a glucometer. The serum was analyzed for lipid profile and Vascular Cell Adhesion Molecule – 1(VCAM 1) by ELISA method before and after treatment. The histopathology of the heart and liver was also performed. Results: The abnormal change in lipid profile, blood glucose, and inflammatory marker along with the accumulation of intracellular fats in the arteries of the heart and liver confirmed dyslipidemia. A significant reduction in serum lipid profile (p < 0.05), blood glucose (p < 0.05), and VCAM 1 (p < 0.05) was noted after the treatment with significant histopathological changes in arteries of the heart and liver. Conclusion: The study provides scientific validation on the drug GTG being effective in hyperglycemia, hyperlipidemia, and inflammation in dyslipidemia.
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U2 - 10.1016/j.jaim.2022.100583
DO - 10.1016/j.jaim.2022.100583
M3 - Article
C2 - 35759880
AN - SCOPUS:85132901300
SN - 0975-9476
VL - 13
SP - 100583
JO - Journal of Ayurveda and Integrative Medicine
JF - Journal of Ayurveda and Integrative Medicine
IS - 3
M1 - 100583
ER -
