Anti-inflammatory activity and skin retention profiles of topically applied diclofenac gels

Topical non-steroidal anti-inflammatory formulations are designed to deliver therapeutic levels of the active ingredient to the inflamed tissues without elevating serum levels after application on the skin. This route is an attractive alternative to the oral administration of NSAIDS, which is associated with high incidence of GIT complications and other systemic toxic effects. Several brands of anti-inflammatory topical preparations including diclofenac gels are now available in the Indian market.