Anti-inflammatory activity of niosome encapsulated diclofenac sodium in arthritic rats

R. A.R. Naresh, G. K. Pillai, N. Udupa, G. Chandrashekar

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56 Citations (Scopus)


Synthetic analogues of liposomes prepared from non-ionic surfactants, known as niosomes, have been used as vesicular drug carriers. Diclofenac sodium has been entrapped in niosomes comprising Tween 85 and Tween 85- poloxamer F 108 mixture. Anti-inflammatory efficacy of these niosomes were compared with that of free diclofenac sodium in adjuvant induced arthritic rats. It was found that the niosomal diclofenac sodium formulations prepared by employing a 1:1 combination of Tween 85 and poloxamer F 108 elicits a better and consistent anti-inflammatory activity for more than 72 hours after administration of a single dose.

Original languageEnglish
Pages (from-to)46-48
Number of pages3
JournalIndian Journal of Pharmacology
Issue number1
Publication statusPublished - 1994

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)


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